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Organothiophosphates have found widespread application as biologically active compounds and synthetic intermediates in medicinal chemistry. The first transition‐metal‐free one‐pot direct synthesis of heterocyclic phosphorothioates involving indole or imidazo[1,2‐a]pyridine derivatives, elemental sulfur, and P(O)H compounds is presented. The use of NaI or KI as a catalyst, tert‐butyl hydroperoxide as an oxidant, various indole and imidazo[1,2‐a]pyridine derivatives are tolerant in this transformation, affording the corresponding products in good to excellent yields. Moreover, this method can be easily adapted to large‐scale preparation. O,O‐Diethyl S‐(1‐phenyl‐1H‐indol‐3‐yl) phosphorothioate presents potent anti‐inflammatory activity in lipo.
Oral Diseases 04/22/2019 21:12
Abstract. Objectives. Mitophagy is an important mitochondrial quality control mechanism. In this study we investigated the mitochondrial damage and mitophagy occurred in inflammatory human dental pulp and lipopolysaccharide‐stimulated preodontoblasts. Materials and Methods. In dental pulp tissues and lipopolysaccharide‐stimulated preodontoblasts, immunofluorescences and western blot were performed to detected the expression of mitochondrial and mitophagy‐related proteins, autophagy markers were also examined. Reactive oxygen species generated by mitochondria were examined by MitoSOX. Transmission Electron Microscope was used to examine the morphology of mitochondria in lipopolysaccharide‐stimulated preodontoblasts. Results. The active fission a.
博華太平洋(01076)宣布,位於塞班島的第一期娛樂度假村項目「博華皇宮‧塞班」將於今年9月30日或以前部分. 開業。. 全文:博華塞班島項目首期9月底部分開業 信報財經新聞有限公司版權所有,不得轉載。Copyright © 2019 Hong Kong Economic Journal Company Limited. All rights.
The Thaiger (Thailand) 04/22/2019 21:07
PHOTOS: Facebook/Ying Yupa Anan Don’t leave your mobile phone in your car if it’s going to be parked outside in the hot Thai sun. That’s the take-away message after an exploding mobile phone punched a hole in this woman’s pick-up truck windscreen after leaving the phone sitting on the dash. Samut Prakan, south of Bangkok […]. The post Beware exploding phones – warning about leaving phones in hot cars appeared first on The Thaiger Thailand news .
Macau Daily Times (China) 04/22/2019 21:06
The government’s study group for the criminalization of illegal guesthouses is now organizing collected opinions concerning the topic, according to the director of the Macau Government Tourism Office (MGTO), Helena de Senna Fernandes. The group, led by the Secretary for Administration and Justice, Sonia Chan, was formed approximately four months ago. During this time, it […]. The post Government sorting opinions on illegal guesthouses appeared first on MACAU DAILY TIMES 澳門每日時報 . (Indonesia) 04/22/2019 21:04 – Presiden Joko Widodo mengundang para gubernur se-Indonesia ke Istana Negara, Jakarta pada Senin (22/4). Pertemuan itu memang tidak diumumkan dalam agenda harian Presiden. Diketahui, kedatangan para kepala daerah itu untuk membahas tentang pengembangan infrastruktur dan aspek-aspek pembangunan lainnya. Meski demikian, suasana Pilpres 2019 masih amat kental terasa. Beberapa gubernur yang hadir adalah mereka […] 04/22/2019 21:04
ResApp's smartphone-based algorithms have demonstrated a high degree of accuracy in diagnosing acute respiratory disease in a pivotal adult clinical study - achieving greater than 86% positive and negative percent agreement for lower respiratory tract disease and pneumonia when compared with clinical diagnosis Study also showed that ResApp's algorithms accurately identified acute exacerbations in patients with chronic obstructive pulmonary disease (COPD) or asthma, and were able to accurately screen for COPD in a broad general population Brisbane, Australia, 23 April 2019 - ResApp Health Limited (ASX:RAP), a leading digital health company developing smartphone applications for the diagnosis...
ITWire 04/22/2019 21:03
Melbourne-based Elenium Automation has completed a $15 million capital raising with funding from high profile investors as it continues the design, development and manufacture of self-service and automation technologies for the aviation sector. The Series A capital raising was spearheaded by Acorn Capital and was supported by Cibus Group, Harris Carlson and Herbert Smith Freehills for the completion of the transaction. Elenium says its automation technologies for aviation are designed to reduce passenger congestion by up to 60% whilst enhancing revenues and delivering a better customer experience. Launching just over three years ago, Elenium says it now employs over 50 staff and has more than 600 check-in kiosks in use by 50 airlines across.


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