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PubMed News (NIH) 01/21/2020 23:00
Contributors : Muralidhara R Maradana ; Brendan J O'Sullivan ; Ranjeny Thomas Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Non-alcoholic fatty liver disease (NAFLD) is a common complication of obesity, where insulin resistance and hepatocyte fat deposition may progress to steatohepatitis (NASH) and fibrosis/ cirrhosis.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Laura L Kiessling ; Sayaka Masuko Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Purpose: The goals of this study are to identify whole transcriptomic changes between undifferentiated wildtype (H9 cell line) and undifferentiated EXT1-/- human embryonic stem cells using RNA-seq.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Gretchen A Meyer ; Kathryn L Bohnert ; Paul Gontarz ; Bo Zhang Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. DPN muscle exhibits features of degeneration with attempted regeneration. In the most severely pathological muscle samples, regeneration appears to be stymied and our data suggest that this may be partly due to intrinsic dysfunction of the satellite cell pool in addition to extrinsic structural pathology (e.g. nerve damage).
PubMed News (NIH) 01/21/2020 23:00
Contributors : Atsushi Oba ; Shu Shimada ; Yoshimitsu Akiyama ; Taketo Nishikawaji ; Kaoru Mogushi ; Hiromitsu Ito ; Satoshi Matsumura ; Arihiro Aihara ; Yusuke Mitsunori ; Daisuke Ban ; Takanori Ochiai ; Atsushi Kudo ; Hiroshi Asahara ; Atsushi Kaida ; Masahiko Miura ; Minoru Tanabe ; Shinji Tanaka Series Type : Expression profiling by array Organism : Homo sapiens. Background & Aims: Recent genomic studies have identified frequent mutations of AT-rich interactive domain 2 (ARID2) in hepatocellular carcinoma (HCC), but it is not still understood how ARID2 exhibits tumor suppressor activities.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Wei-Yi Chen ; Xiaoling Wang ; Rebert G Roeder Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. Mammalian cells contain two isoforms of RNA Polymerase III (Pol III) that differ in only a single subunit, with POLR3G in one form and the related POLR3GL in the other form.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Singh Richard ; Verstraeten Bruno ; Siddique Shahid ; Tegene Adelahu ; Tenhaken Raimund ; Frei Michael ; Haeck Ashley ; Demeestere Kristof ; Pokhare Somnath ; Gheysen Lieve ; Kyndt Tina Series Type : Expression profiling by high throughput sequencing Organism : Oryza sativa Japonica Group. Ascorbic acid (AA) is known to play a vital role in plant growth and detoxification of reactive oxygen species, however little is known about the significance of AA oxidation in plant defence against pathogens.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Hyun Lee ; Dong-Min Yu ; Jun-Sub Park ; Hwayeon Lee ; Jun-Seok Kim ; Seung-Hoi Koo ; Jae-Seon Lee ; Sungsoo Lee ; Young-Gyu Ko Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Purpose: The function of Prom1, a penta-transmembrane glycoprotein which is a used as cancer stem cell marker, in the liver is unclear.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Sara B Jager ; Franziska Denk ; Stephen McMahon ; Christian B Vægter Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. For the first time, we here characterize the transcriptional signature of satellite glial cells (SGCs) in a nerve injury-paradigm by isolating SGCs from mouse dorsal root ganglia (DRGs) after peripheral nerve injury followed by next generation RNA sequencing (RNA-seq).
PubMed News (NIH) 01/21/2020 23:00
Contributors : Gaelle Cordonnier ; Amit Mandoli ; Nicolas Cagnard ; Guillaume Hypolite ; Laura Jussen ; Ludovic Lhermitte ; Els Verhoeyen ; Vahid Asnafi ; Niall Dillon ; Elizabeth Macintyre ; Joost Martens ; Jonathan Bond Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Polycomb activity is frequently altered in acute leukaemia through mutation or deletion of Polycomb Repressive Complex (PRC) components.
PubMed News (NIH) 01/21/2020 23:00
Contributors : Natasha L Patel-Murray ; Ernest Fraenkel Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. High-throughput screening and gene signature analyses frequently identify lead therapeutic compounds with unknown modes of action (MoAs), and the resulting uncertainties can lead to the failure of clinical trials.
PubMed News (NIH) 01/21/2020 23:00
Contributors : M J den Broeder ; J Ballangby ; L M Kamminga ; P Aleström ; J Legler ; L.C Lindeman ; J.H Kamstra Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Danio rerio. Recent studies indicate that exposure to environmental chemicals may increase susceptibility to developing metabolic diseases.

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