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Annals of Internal Medicine 09/16/2019 17:48
Background:. Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown. Objective:. To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups. Design:. Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial.
Annals of Internal Medicine 09/16/2019 17:48
A sharp decline in clinical trials has occurred, whether measured as number of trials performed, number of participants enrolled, or number of investigators. This commentary discusses factors contributing to an environment that does not promote clinical trial research and offers suggestions for actions that academic health centers can take to counter these pressures.
Annals of Internal Medicine 09/16/2019 17:48
Candida auris. is an emerging, multidrug-resistant yeast that is now known to have caused invasive infections in more than 30 countries spanning every inhabited continent. It is an urgent antimicrobial resistance threat because many strains are resistant to at least 2 of 3 major classes of antifungal drugs and because it causes outbreaks in health care settings to an extent not seen with other. Candida. species.
Annals of Internal Medicine 09/16/2019 17:48
The expanded use of opioids for chronic pain has created a population of patients prescribed long-term opioid therapy at doses that are often above those recommended by the Centers for Disease Control and Prevention. Many patients may benefit from tapering to lower, safer doses. This commentary argues that successful tapering requires implementing and incentivizing tapering protocols, recognizing prescription opioid dependence as a distinct clinical condition necessitating treatment, and expanding the indication for buprenorphine.

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