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PubMed News (NIH) 07/04/2020
Contributors : Fangfang Song ; Baifeng Zhang Series Type : Expression profiling by array Organism : Homo sapiens. Altered methylation patterns in HGSOC were further characterized by gene expression profiles. By integrating DNA methylation and mRNA expression data, we identified genes with negative and positive correlation, aiming to identify molecular drivers and pathways that are HGSOC-related.
Epithelial-derived high-grade serous ovarian cancer (HGSOC) is the deadliest gynecologic malignancy. Roughly 80% of patients are diagnosed with late-stage disease, which is defined by wide-spread cancer dissemination throughout the pelvic and peritoneal cavities. HGSOC dissemination is dependent on tumor cells acquiring the ability to resist anoikis (apoptosis triggered by cell detachment). Epithelial cell detachment from the underlying basement membrane or extracellular matrix leads to cellular stress, including nutrient deprivation. In this report, we examined the contribution of fatty acid oxidation (FAO) in supporting anoikis resistance. We examined expression Carnitine Palmitoyltransferase 1A (CPT1A) in a panel of HGSOC cell lines cult.
PubMed News (NIH) 07/02/2020
Contributors : Ye Hu ; Barbie Taylor-Harding ; Sandra Orsulic Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Matched high-grade serous ovarian carcinoma samples collected from the ovary (ov), omental metastasis (om-met), and non-omental intraperitoneal metastasis (met) from 10 patients at the time of primary debulking surgery were analyzed for RNA expression by RNA sequencing.
Purpose:. Clear cell ovarian carcinoma (CCOC) is an aggressive disease that often demonstrates resistance to standard chemotherapies. Approximately 25% of patients with CCOC show a strong APOBEC mutation signature. Here, we determine which APOBEC3 enzymes are expressed in CCOC, establish clinical correlates, and identify a new biomarker for detection and intervention. Experimental Designs:. APOBEC3 expression was analyzed by IHC and qRT-PCR in a pilot set of CCOC specimens ( n = 9 tumors). The IHC analysis of APOBEC3B was extended to a larger cohort to identify clinical correlates ( n = 48). Dose-response experiments with platinum-based drugs in CCOC cell lines and carboplatin treatment of patient-derived xenografts (PDXs) were done to addres.
Using biopsies of metastatic high-grade serous ovarian cancer (HGSOC) that ranged from minimal to extensive disease, we defined RNA and protein profiles that evolved with changes in cellularity, architecture, and tissue modulus. This gave new insights into host response to cancer as well as leukocyte, cytokine, and matrisome regulation in the tumor microenvironment (TME). Although we had studied a single metastatic site, we identified an extracellular matrix (ECM) gene expression signature, which we named the matrix index, that significantly associated with increased stiffness and disease score. High matrix index distinguished patients with a shorter overall survival in ovarian and twelve other primary cancers, suggesting a common matrix re.

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