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There is a perception that developing medical devices is hard — so hard that it scares off a lot of people with otherwise great ideas. Indeed, it is reported that 90% of innovations fail — a figure that is likely to be higher in the active medtech space, given that the regulatory requirements for medical devices involving electricity are more onerous than for inert products. Of course there are always exceptions, and one device that is currently experiencing some success is MOSkin — a sensing technology for measuring the effective depth and intensity of radiation doses in real time during radiotherapy treatments. The technology was created by the at the and is being commercialised by , with the next stage of commercialisation being to devel.

Our genetic sequence is generally the same in all cells in our body. However, throughout our lifetime, epigenetic modifications can change the way genes are expressed, without altering the gene itself, affecting how a single cell or small groups of cells (cell types) function. Due to their significant effects on cellular function and their dynamic nature, epigenetic changes play critical roles in development and disease. Mapping the epigenome greatly facilitates our understanding of the epigenetic mechanisms underlying cellular differentiation and disease. The epigenome includes multiple types of modifications that can be different in each cell and can change over time, such as methylation, histone modifications, nucleosome positioning, hig.

Scientific equipment supplier has announced the addition of ’s bioengineering platform for cell biology to its product portfolio. The Alvéole platform allows users to convert an existing microscope into an automated bioengineering system for the engineering of smart cell culture substrates. Alvéole is a French-based manufacturer specialising in designing tools for engineering more reproducible in vitro cell microenvironments. This allows researchers working in areas such as proteins and drug discovery to take control of the cellular microenvironment by giving them improved control over experimental conditions. In doing so, they can produce in vivo-like environments that accelerate cell biology research by producing cell studies with increas.

The Australian Government is looking to maximise the economic potential of the medicinal cannabis industry, with Major Project Status granted to Hydroganics — for a multistage $333 million medicinal cannabis facility in South East Queensland — and to , with its medical division , for a $70 million facility in regional Victoria. In addition to creating 140 ongoing jobs, at full production Hydroganics is expected to produce an estimated turnover of $366 million; 90% of the turnover will be generated from exporting overseas.

US researchers have discovered a brain circuit that controls alcohol drinking behaviour in mice, and can be used as a biomarker for predicting the development of compulsive drinking later on. Published in the journal , their findings could potentially have implications for understanding human binge drinking and addiction in the future. Although alcohol use is ubiquitous in modern society, only a portion of individuals develop alcohol use disorders or addiction — yet scientists have not understood why some individuals are more prone to develop drinking problems. And while previous research has focused on examining the brain after a drinking disorder develops, the ’s Professor Kay Tye and her team sought to discover the brain circuits that ar.

The (ESA) has released a statement calling for governments, universities and industry to stop the censorship and suppression of science and scientists, which they say is keeping the media, public and even policymakers in the dark on topics ranging from bushfires to species extinctions. The statement, which has been endorsed by 600 scientists, was developed in response to a survey of ESA members that revealed extensive and deeply concerning evidence of suppression of research results and professional advice in government, environmental consultancies and universities.

An international team of astronomers, led by Professor Jifeng Liu at the , has discovered that some black holes may be born more than twice the size than previously thought — a breakthrough that has now been published in the journal . The astronomers surveyed the sky with the LAMOST optical telescope in north-east China to look for stars that orbit around an invisible object, pulled by its gravity.

As explained by Professor Pierre Vanderhaeghen, from the and , “One remarkable feature of human neurons is their unusually long development. Neural circuits take years to reach full maturity in humans, but only a few weeks in mice or some months in monkeys. “This long period of maturation allows much more time for the modulation of brain cells and circuits, which allows us to learn efficiently for an extended period up until late adolescence. It’s a very important and unique feature for our species, but what lies at its origin remains a mystery.”Dr Daniele Linaro, also from VIB-KU Leuven and Université libre de Bruxelles, revealed, “We differentiated human embryonic stem cells into neurons and injected them into the brains of young mouse p.

In a laboratory, the safety of researchers, scientists, staff and visitors depends on adequate communication and training. They must be able to identify the potential for accidents within the lab setting and be aware of procedures and policies to minimise risks and ensure the safety of all involved. Safety signage is an effective way to regularly remind all employees, contractors and visitors of their safety responsibilities and it can assist with everything from chemical and biological hazards to infection control alerts, personal protective equipment (PPE) education and streamlining the organisation’s processes. The correct signage helps important research to continue efficiently without interruption or accident. During an emergency or cr.

The effectiveness of current treatments for melanoma could be improved by using approaches that wipe out the ‘survival system’ of cancer cells, according to a study conducted by UK researchers and published in the journal . There are around 16,000 new melanoma skin cancer cases in the UK every year, with late-stage melanoma evolving rapidly to resist treatment.

Professor Andreas Strasser and Professor David Vaux, both of Melbourne’s (WEHI), have been awarded the CSL Florey Medal, presented biennially by the (AIPS) for significant achievements in biomedical science and/or human health advancement. Together, the two scientists provided the first insights into the molecular mechanisms for cell death, and the first evidence that the failure of cells to undergo programmed death can lead to cancer and autoimmune disease.

Researchers from have revealed how nanoparticles could be used to identify the presence of invasive and sometimes deadly microbes, as well as to deliver targeted treatments more effectively. Their work has been published in the journal . Candida albicans , a commonly found microbe, can turn deadly when it colonises on devices such as catheters implanted in the human body. While commonly found in healthy people, the microbe can become a serious problem for those who are seriously ill or immune-suppressed. It forms a biofilm when it colonises using, for example, a catheter as a source of infection, then spreads into the bloodstream to infect internal organs. “The mortality rate in some patient populations can be as high as 30–40% even if you

Conventional nanoparticle manufacturing methods can be sensitive to reaction conditions, difficult to reproduce, labour intensive and challenging to scale. NanoAssemblr Ignite solves these significant issues and allows scientists to create transformative medicines at the bench scale. It paves the way for new nanomedicine-based gene and cell therapies, as well as small molecule- and protein-based drugs to treat cancer, rare disease and infectious disease. NanoAssemblr Ignite is designed to make preclinical laboratory-scale nanoparticle production efficient, reproducible and tuneable. Validated by over 100 peer-reviewed publications, the system is fast, simple and intuitive to operate. Nanomedicines are prepared in less than a minute, allowin.

Bovogen Biologicals’ foetal bovine serum (NZ origin) is manufactured in a fully validated sterile filtration facility, following strict GMP process, and is fully traceable. The FBS manufacturing process follows a strict quality controlled protocol. All batches of FBS are triple 0.1 μm sterile filtered in a validated aseptic sterile filtration suite using a fully disposable closed loop filtration train. The closed-loop filtration system is fully disposable to ensure that all product contact parts are only used once, minimising any risk of contamination or human error. The company’s latest product release is the Bovogen Ultra Low IgG FBS. Using a proprietary chromatographic process, IgG has been removed from the FBS with the ultimate goal of

Published in the journal , the research builds on Professor Sven Pettersson’s earlier studies on how transplantation of gut microbes from healthy mice can restore muscle growth and function in germ-free mice with muscle atrophy, which is the loss of skeletal muscle mass. The latest study saw Prof Pettersson and his team from Singapore, the UK and Australia transplant gut microbes from old mice (24 months old) into young, germ-free mice (six weeks old).

Researchers from the (KAUST) have shown how a standard microscope can be adapted to provide even more information, thanks to the use of an innovative optical component and a reconstruction algorithm. Their work has been published in the journal . In its simplest form, microscopy creates an image of an object by measuring the intensity of light passing through it. This requires a sample that scatters and absorbs light in different ways. Many living cells, however, absorb very little visible light, meaning that there is only a small difference between light and dark regions, known as the contrast. This makes it difficult to see the finer detail. The light passing through the sample changes not only its intensity, but also its phase: the relat.

There were 219 million cases of malaria worldwide in 2017, leading to an estimated 435,000 deaths. As explained by research leader Associate Professor Alyssa Barry, malaria parasites grow within red blood cells, where they insert proteins (known as PfEMP1) into the surface. “As part of their survival strategy within the human host, malaria parasites use PfEMP1 to stick to the walls of blood vessels, and this can cause blockages to blood flow and inflammation, leading to severe disease,” said Assoc Prof Barry, who heads the Translational Genomics Group at the . “Malaria parasites change these proteins to escape from developing immune responses, and every strain has a different set of proteins, making the identification of vaccine targets lik.

Ever since in vitro fertilisation became a reality and scientists began pre-screening embryos for genetic disorders, the fantasy of creating ‘designer babies’ has taken hold of the public’s imagination. But just how far has reproductive science developed when it comes to selecting for traits such as height and IQ? Currently, the most practical approach to genetic ‘enhancement’ of embryos is preimplantation genetic screening of IVF embryos. Selecting embryos for eye colour or sex is relatively easy for a scientist to perform, as it involves only one or very few genes, as is screening for genetic diseases caused by a single mutation. But according to a recent study, led by Dr Shai Carmi at and published in the journal the ability to select fo.

Forensic scientists now have access to the Applied Biosystems SeqStudio Genetic Analyzer for Human Identification — an easy-to-use capillary electrophoresis (CE) platform that is designed to obtain gold-standard quality STR-based DNA profiles without compromising performance. Released by Thermo Fisher Scientific, the platform is designed for small to medium-sized forensic DNA analysis and paternity laboratories and has been validated according to Scientific Working Group on DNA Analysis Methods (SWGDAM) guidelines across a broad range of Applied Biosystems STR Amplification Kits.

Researchers from the have reported that medroxyprogesterone acetate (MPA), the active ingredient in the common contraceptive injection Depo-Provera, can prevent the development of cervical cancer in mice with precancerous lesions. The drug also decreased existing precancerous lesions. Cervical cancer is the third most common and third most deadly cancer in women worldwide. Human papillomavirus (HPV) is considered a major factor in the development of cervical precancerous lesions and cancers — but although HPV vaccines are effective at preventing HPV infections, they may not be readily available to women in underdeveloped countries and those of low socioeconomic status. And while surgical removal of precancerous lesions (cervical intraepithe.

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