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Benzinga 09/17/2019 16:35
The thinly traded micro-cap biotech vTv Therapeutics Inc (NASDAQ: ) is on investors' radars ahead of a Sept. 18 poster presentation of clinical data. The company is set to present at the European Association for the Study of Diabetes 55th annual meeting with results from the Part 1 of the Phase 2 Simplici-T1 study of liver-selective glucokinase activator TTP399 as an adjunctive treatment for Type 1 diabetes. The Pipeline. vTv has six products in its clinical pipeline, with three Phase 2 assets: azeliragon for Alzheimer's disease, TTP399 for Type 1 and Type 2 diabetes and TTP273 for Type 2 diabetes. Azeliragon. codenamed TTP488, is an orally administered, small molecule antagonist targeting the receptor of advanced glycation endproducts, or RA.
ENDPOINTS 09/17/2019 05:00
Psychedelics have experienced recent years amid a torrent of preclinical and clinical research suggesting it might provide a path to treat mood disorders conventional remedies have only scraped at. Now a preclinical trial from a young biotech suggests at least one psychedelic compound has effects beyond the mind, and — if you believe the still very, very early hype — could provide the first single remedy for some of the main complications of obesity. A study in mice funded by Eleusis and published in Scientific Reports found a long-known drug called ®-DOI could be used to treat cardiovascular disease, reducing inflammation in the aorta, decreasing overall and HDL cholesterol levels, and potentially curbing diabetes by increasing glucose tol.
Innovations-Report (EU) 09/16/2019 10:35
Researchers at the Complutense University of Madrid (UCM) have identified changes in retinal layer thickness, inflammation or thinning in patients with mild Alzheimer's disease, confirming that the retina is one of the most important biomarkers for early diagnosis of the disease. For the first time, researchers have determined the shape and size of the areas that present significant thinning in each retinal layer, which tend to occur in...
PubMed News (NIH) 09/16/2019
Contributors : Christoph Gericke ; Anna Mallone ; Britta Engelhardt ; Roger M Nitsch ; Maria T Ferretti Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. The goal of this study is to investigate the involvement of inflammation in Alzheimer’s disease (AD) and to clarify the signaling pathways involved in the presence of beta-amyloidosis, a hallmark of AD pathogenesis, to help identifying potential targets for therapy.
Benzinga 09/11/2019 07:30
Presenting New Clinical Data from Phase 2 Study in Type 1 Diabetes with Liver Selective GKA Program. Pre-Clinical Data in NASH with the NRF2/Bach1 Program. HIGH POINT, N.C., Sept. 11, 2019 (GLOBE NEWSWIRE) -- (NASDAQ:), a clinical-stage biopharmaceutical company with leading programs focused on the development of orally administered treatments for diabetes, Alzheimer's disease and inflammatory disorders, today announced it will be presenting posters with new clinical and pre-clinical data from the company's Liver Selective GKA Program and its ...

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