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European Respiratory Journal 10/10/2019 03:05
Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH). To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (PASMCs) collaborate to stimulate PASMC growth and whether the CCL2-CCR2 and CCL5-CCR5 pathways inhibited macrophage–PASMC interactions and PAH development, we used human CCR5-knock-in mice and PASMCs from patients with PAH and controls. Conditioned media from murine M1 or M2 macrophages stimulated PASMC growth. 10/09/2019 10:46
Conditions : Hypertension; Dyslipidemias Interventions : Drug: OLOMAX 20/5/5mg; Drug: OLOMAX 20/5/10mg; Drug: Olmesartan 20 mg/Amlodipine 5 mg Sponsor : Daewoong Pharmaceutical Co. LTD. Recruiting.

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