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PubMed News (NIH) 05/31/2020
Contributors : Liu Yuan ; Zhu Zhou Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. A large-panel gene expression analysis was conducted to identify biomarkers associated with the effectiveness of adding palbociclib to letrozole Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have demonstrated significant activity in estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) advanced breast cancer.
PubMed News (NIH) 05/31/2020
Contributors : Sebastian Reichert ; Patrick Ebner ; Eve-Julie Bonetti ; Arif Luqman ; Mulugeta Nega ; Jacques Schrenzel ; Cathrin Spröer ; Boyke Bunk ; Jörg Overmann ; Peter Sass ; Patrice François ; Friedrich Götz Series Type : Expression profiling by array Organism : Staphylococcus aureus. In this study we addressed the question how a mevalonate (MVA)-auxotrophic Staphylococcus aureus ΔmvaS mutant can revert to prototrophy.
PubMed News (NIH) 05/31/2020
Contributors : Tomas Venit ; Piergiorgio Percipalle ; Chris Toseland ; Nizar Drou Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. During transcription, RNA Polymerase II (RNAPII) is spatially organised into clusters that correlate with transcription activity.
PubMed News (NIH) 05/31/2020
Contributors : Kumiko Nakada-Tsukui ; Konomi Marumo ; Tomoyoshi Nozaki Series Type : Expression profiling by high throughput sequencing Organism : Entamoeba histolytica. To know the role of lysosomal hydrolase receptors in virulecne of enteric protozoan parasite Entamoeba histolytica, eleven cysteine protease binding protein family (CPBF) proteins were specifically silenced and examined the effect on virulence-related phenotypes.
PubMed News (NIH) 05/31/2020
Contributors : Yejie Shi ; Jun Chen Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Senescence-associated alterations in microglia may have profound impact on cerebral homeostasis and stroke outcomes. However, the lack of a transcriptome-wide comparison between young and aged microglia in the context of ischemia limits our understanding of aging-related mechanisms. Herein, we performed bulk RNA sequencing analysis of microglia purified from cerebral hemispheres of young adult (10-week-old) and aged (18-month-old) mice 5 days after distal middle cerebral artery occlusion or sham operation. Considerable transcriptional differences were observed between young and aged microglia in healthy brains, indica.
PubMed News (NIH) 05/31/2020
Contributor : Nehad M Alajez Series Type : Expression profiling by array Organism : Homo sapiens. We have employed whole genome microarray to identify changes in gene expression in MDA-MB-231 cells transfected with hsa-miR-205-5p and hsa-miR-214-3p compared to scrambled miRNA precursors at 72 hours after transfection.
PubMed News (NIH) 05/31/2020
Contributors : Theresa E León ; Tanya Rapoz-D’Silva ; Cosetta Bertoli ; Sunniyat Rahman ; Michael Magnussen ; Brian Philip ; Nadine Farah ; Simon E Richardson ; Sara Ahrabi ; Jose A Guerra-Assunção ; Rajeev Gupta ; Elisabeth Nacheva ; Javier Herrero ; David C Linch ; Stephen Henderson ; Robertus de Bruin ; Marc R Mansour Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Loss-of-function mutations of EZH2, the enzymatic component of PRC2, have been associated with poor outcome and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL).
PubMed News (NIH) 05/31/2020
Contributors : Gian L Vita ; M'Hammed Aguennouz ; Francesca Polito ; Rosaria Oteri ; Massimo Russo ; Luca Gentile ; Cristina Barbagallo ; Marco Ragusa ; Carmelo Rodolico ; Rosa M Di Giorgio ; Antonio Toscano ; Giuseppe Vita ; Anna Mazzeo Series Type : Non-coding RNA profiling by array Organism : Homo sapiens. Transthyretin variant amyloidosis (ATTRv) is a rare autosomal dominant disease characterized by the accumulation of amyloid in many organs, mostly causing a sensory-motor neuropathy, cardiomyopathy, and dysautonomia.
PubMed News (NIH) 05/31/2020
Contributors : Duncan Coleman ; Keiko Sugimoto Series Type : Expression profiling by high throughput sequencing Organism : Arabidopsis thaliana. Plants form callus and regenerate new organs when incubated on phytohormone-containing media. While accumulating evidence suggests that these regenerative processes are governed by transcriptional networks orchestrating stress responses and developmental transitions, it remains unknown if post-translational regulatory mechanisms are involved in this process. Here, we find that SIZ1, which encodes an E3 ligase catalyzing attachment of the SMALL UBIQUITIN-LIKE MODIFIER (SUMO) to proteins, regulates wound-induced signal transduction and organ regeneration. We show that loss-of-function mutants for SIZ1.
PubMed News (NIH) 05/31/2020
Contributors : Xiaoling Jiang ; Zhaowei Cai ; Zhilan Xiao ; Huazhen Liu ; Li Liu Series Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencing Organism : Mus musculus. In this study we performed a systematic analysis of the non-coding RNA (ncRNA) transcriptomes of the Down Syndrome (DS) developing hippocampus using the DS mouse model Dp16(1)Yey.
PubMed News (NIH) 05/31/2020
Contributors : Xiao-Hong Sun ; Constantin Georgescu Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Group 2 innate lymphoid cells (ILC2s) represent a subset of newly discovered immune cells that are involved in immune reactions against microbial pathogens, host allergic reactions as well as tissue repair.
PubMed News (NIH) 05/31/2020
Contributors : Yeeun Choi ; Woong-Jae Jung Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived liver transcriptome profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods and to evaluate protocols for optimal high-throughput data analysis Methods: Liver mRNA profiles of 8-week-old wild-type (WT) and liver specific conditional CTCF KO (CTCF cKO) mice were generated by deep sequencing, in quadruplet, using Illumina GAIIx. The sequence reads that passed quality filters were analyzed at the tra.
PubMed News (NIH) 05/31/2020
Contributors : Fei Gao ; Yayan Feng Series Type : Other Organism : Trichinella britovi ; Trichinella murrelli ; Trichinella nativa ; Trichinella nelsoni ; Trichinella papuae ; Trichinella patagoniensis ; Trichinella pseudospiralis ; Trichinella sp. T6 ; Trichinella sp. T8 ; Trichinella sp. T9 ; Trichinella spiralis ; Trichinella zimbabwensis. Apart from SNPs, we also dissected the association between epigenome variation and structural variation, to reveal the correlation between epigenomic diversity and genome structural variation. To reveal the correlation between epigenomic diversity and genome structural variation, we first identified DMRs of T4 with other eleven Trichinella species. Overall, we found that approx. 50% of the DMRs were at
PubMed News (NIH) 05/31/2020
Contributors : Kameron B Rodrigues ; Matthew J Dufort ; Alba Llibre ; Vincent Bondet ; Cate Speake ; Kristin V Tarbell ; Darragh Duffy Series Type : Expression profiling by array Organism : Homo sapiens. TruCulture human whole blood ex vivo stimulation was performed on 17 healthy individuals and 17 post-onset type 1 diabetics, then gene expression was analyzed using Nanostring to characterize stimulated innate immune responses.
PubMed News (NIH) 05/31/2020
Contributors : Cyrill Géraud ; Carolina Delatorre Series Type : Expression profiling by array Organism : Mus musculus. Due to their ligand profiles, it can be hypothesized that Stab1 and Stab2 may be involved in atherosclerosis. We treated mouse aorta endothelial cells (MAOEC) with plasma from Stabilin-deficient and Wildtype mice to account for gene changes. We used microarrays to detail the global programme of gene expression in MAOEC during different plasma treatments. We identified distinct classes of up- and down-regulated genes in response to the treatment.

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