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PubMed News (NIH) 10/21/2020
Contributor : Trine Folseraas. Series Type : Expression profiling by array Organism : Homo sapiens. Based on the identification of a transcriptomic signature, including Slit2, characterizing portal mesenchymal stem cells (PMSC) and derived myofibroblast (MF), we examined the gene expression profile of in liver tissue derived from multiple human liver disorders, including primary sclerosing cholangitis (PSC) (n=12), non-alcoholic steatohepatitis (NASH) (n=7) and other liver diseases (i.e., primary biliary cholangitis, autoimmune hepatitis, alcoholic liver disease and haemochromatosis) (n=8) and compared them to healthy controls (tumor free tissue from livers with metastasis from colorectal cancer) (n=5). We found that SLIT2 was overexpressed
PubMed News (NIH) 10/21/2020
Contributors : Micah A Luftig ; Joanne Dai ; Gregory E Crawford ; Lingyun Song Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. BFL-1 is an understudied anti-apoptotic protein that is upregulated in melanoma, certain forms of leukemias and lymphomas, and Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs).
PubMed News (NIH) 10/21/2020
Contributor : Daria Miroshnychenko Series Type : SNP genotyping by SNP array Organism : Homo sapiens. Initiation and progression of cancers reflect the underlying process of somatic evolution, which follows a Darwinian logic, i.e., diversification of heritable phenotypes provides a substrate for natural selection, resulting in the outgrowth of the most fit subpopulations.
PubMed News (NIH) 10/21/2020
Contributors : Nils Rother ; Rik G Lindeboom ; Raphaël Duivenvoorden Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. We demonstrate that hydroxychloroquine inhibits trained immunity at the functional and epigenetic level and is accompanied by reduced expression of interferon-stimulated genes.
PubMed News (NIH) 10/21/2020
Contributors : Stefan Bengtson ; Andrew William ; Sabina Halappanavar ; Ulla Vogel Series Type : Expression profiling by array Organism : Mus musculus. This study investigates transcriptomic differences in the lung and liver after pulmonary exposure to two Graphene based materials with similar physical properties, but different surface chemistry.
PubMed News (NIH) 10/21/2020
Contributors : Magali Taulan-Cadars ; Jessica Varilh Series Type : Non-coding RNA profiling by high throughput sequencing Organism : Homo sapiens. Cystic fibrosis (CF), a genetic disorder, is characterized by chronic lung disease. Small non-coding RNAs are key regulators of gene expression and participate in various processes, which are dysregulated in CF; however, they remain poorly studied. Here, we determined the complete microRNAs (miRNAs) expression pattern in three CF ex-vivo models. The miRNA profiles of air-liquid interface cultures of airway epithelia (bronchi, nasal cells, and nasal polyps) samples from patients with CF and non-CF controls were obtained by deep sequencing. Compared with non-CF controls, several miRNAs were deregula.
PubMed News (NIH) 10/21/2020
Contributors : Tom Alsaigh ; Doug Evans ; David Frankel ; Ali Torkamani Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Atherogenesis involves an interplay of inflammation, tissue remodeling and cellular transdifferentiation (CTD), making it especially difficult to precisely delineate its pathophysiology.
PubMed News (NIH) 10/21/2020
Contributors : Bert Ruiter ; Wayne G Shreffler Series Type : Expression profiling by array Organism : Homo sapiens. Peanut protein is a remarkably potent food allergen in susceptible individuals. The frequency of peanut allergy is approximately 1% in the US population. Peanut allergy often presents with severe symptoms, and it is seldom outgrown. We sought to understand how peanut protein activates human dendritic cells, which are crucial in promoting the activation and differentiation of pathogenic peanut-specific Th2 cells that drive allergic responses.
PubMed News (NIH) 10/21/2020
Contributors : Micah A Luftig ; Joanne Dai ; Gregory E Crawford ; Lingyun Song Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. We performed ATAC-Seq on three freshly dissociated human tonsils sorted to purity into the following B-cell subsets: CD19+ naïve (IgD+/CD38-), memory (IgD-/CD38-), germinal center light zone (IgD-/CD38mid/CD83+/CXCR4lo), germinal center dark zone (IgD-/CD38mid/CD83lo/CXCR4hi), and plasma cells (IgD-/CD38hi).
PubMed News (NIH) 10/21/2020
Contributors : Jijing Luo ; Weijian Cen ; Wenlong Zhao Series Type : Expression profiling by high throughput sequencing Organism : Oryza sativa. To understand how CTS-12 the ABA-dependent multi-levels of regulation, the integration of transcriptomic and metabolomic profiling using the two-way orthogonal projections to latent structures (O2PLS) and OPLS discriminant analysis (OPLS-DA) modeling was performed to investigate the mechanisms underlying chilling tolerance.
PubMed News (NIH) 10/21/2020
Contributors : Magdalena Paolino ; Josef M Penninger Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. In this study we performed RNA sequencing to determine and compare the transcriptome of regulatory T cells (Tregs) present in the thymus, placenta, spleen and white adipose tissue (FAT) of pregnant mice.
PubMed News (NIH) 10/21/2020
Contributors : Lena Illert ; Stefanie Kreutmair ; Geoffroy Andrieux ; Melanie Boerries Series Type : Expression profiling by array Organism : Mus musculus. The F-Box-Protein NIPA might define a novel regulator of aging and critical stress response in hematopoietic stem cells To investigate the underlying mechanisms and activated pathways of NIPA-mediated HSC function in steady state and under stress conditions, we performed Affimetrix-based global gene expression analysis on untreated and irradiated, aged Nipa WT and Nipa KO LSK (Lineage-, SCA1+, cKIT+) cells and identified different expression profiles depending on NIPA.

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