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PubMed News (NIH) 04/21/2019
Contributors : Shaowu Yin ; Guosong Zhang Series Type : Expression profiling by high throughput sequencing Organism : Tachysurus vachellii. we used next-generation sequencing technology to characterise mRNA-seq from five mixed tissues (heart, liver, brain, spleen and kidney) to generate a large amount of P. vachelli transcriptomic reads from multiple tissues.
PubMed News (NIH) 04/21/2019
Contributors : Qiling He ; C S Swindle ; Chao Wan ; Robert J Flynn ; Dongquan Chen ; Christopher A Klug Series Type : Expression profiling by array Organism : Mus musculus. Microarray study revealed 1324 genes that were up-regulated and 1550 genes that were down-regulated more than 1.5 fold change (corrected p <0.05) in MC3T3-E1-derived-mature Osteoblasts compared to control MC3T3-E1.
PubMed News (NIH) 04/21/2019
Contributors : Wei Shi ; Yongfeng Luo ; Matthew Thornton Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Lung mesenchymal knockout of transforming growth factor, beta receptor II (Tgfbr2) will lead to lung malformation, including impaired lung branching and cystic lesion.
PubMed News (NIH) 04/20/2019
Contributors : Yang Chen ; Jingyu Wang Series Type : Expression profiling by array Organism : Homo sapiens. Liver cancer is the fourth deadliest cancer worldwide and is in lack of prognostic indicators. As a p53 inducible gene, GTSE1 (G2 and S phase-expressed-1) showed widely correlation with tumor progress and prognosis in clinical, while its potency as a prognosis indicator or molecular mechanism in regulating cell cycle remain little known. This study aimed to elucidate clinical values and potential functions of GTSE1 in liver cancer. In study of GTSE1 functions, Bel-7404 cell, a human hepatoma cell line, was induced GTSE1-knockdown using lentiviral-mediated RNAi and performed RNA microarray analysis.
PubMed News (NIH) 04/20/2019
Contributor : Bo K Kim Series Type : Expression profiling by array Organism : Homo sapiens. VGLL1 is involved in the regulation of proliferation and metastasis in gastric cancer cells and in vivo mouse models. To understand the downstream regulation of VGLL1, we conducted a microarray analysis of VGLL1 siRNA-treated NUGC3 cells.
PubMed News (NIH) 04/20/2019
Contributors : Min Zhang ; Jason Westin ; Zhiqiang Wang ; Larry W Kwak ; Sattva S Neelapu ; Wencai Ma ; R E Davis Series Type : Expression profiling by array Organism : Homo sapiens. Excisional biopsies of lymph nodes involved by follicular lymphoma (FL) were obtained from previously-untreated, advanced-stage patients to generate heterohybridomas and idiotype vaccine for a clinical trial (PMID: 21632504).
PubMed News (NIH) 04/20/2019
Contributors : Huynh Nhan ; King-Jones Kirst Series Type : Expression profiling by high throughput sequencing Organism : Drosophila melanogaster. We report the genome-wide profiling of hand-dissected ring glands that expressed one of the six flag-tagged transgene: IRP1AWT and IRP1BWT, which are both wild-type; IRP1AC450S and IRP1BC447S, both of which can only assume the apo-form; as well as IRP1A3R3Q and IRP1B3R3Q, both of which are presumed to be non-RNA-binding.
PubMed News (NIH) 04/20/2019
Contributor : Joe Matarlo Series Type : Other Organism : Homo sapiens. HCT-116 cell lines were treated with bPGN and treated cells were harvested at time-point 0, 1hour and 24hours. Identification of RNA-interacting pharmacophores could provide new chemical probes and potentially novel RNA-based therapeutics. Herein, using a high-throughput differential scanning fluorimetry assay, we identified small molecule natural products with the capacity to bind the discrete stem-looped structure of pre-miR-21. The most potent compound identified was a prodiginine-type compound, butylcylcoheptyl prodiginine (bPGN), with the ability to inhibit Dicer-mediated processing of pre-miRNA-21 in vitro and in cells. Time dependent RT-qPCR, western blot, and tran.
PubMed News (NIH) 04/20/2019
Contributors : E Dambroise ; T Bourquard ; M Simion ; J S Joly Series Type : Expression profiling by high throughput sequencing Organism : Oryzias latipes. WDR12 is a ribosome biogenesis factor known to be expressed in Optic tectum Neuroepithelial cells, we define the transcriptome profile of the optic tectum neuroepithelial cells, by cell-sorting followed by RNA-seq (Illumina technology).
PubMed News (NIH) 04/20/2019
Contributors : Hilaree N Frazier ; Adam O Ghoweri ; Emily Sudkamp ; Eleanor S Johnson ; Katie L Anderson ; Grant Fox ; Keomany Vatthanaphone ; Kia Megfan ; Lin Ruei-Long ; Kendra E Hargis-Staggs ; Nada M Porter ; James R Pauly ; Eric M Blalock ; Olivier Thibault Series Type : Expression profiling by array Organism : Rattus ; Rattus norvegicus. Intranasal insulin is a safe and effective method for ameliorating memory deficits associated with pathological brain aging.
PubMed News (NIH) 04/20/2019
Contributors : Yihuan Zhang ; Yongting Yu ; Bing Guo Series Type : Expression profiling by high throughput sequencing Organism : Nicotiana tabacum. Comparative transcriptome analysis was performed to study gene expression profiles in resistant (Yanyan 97, YY97, 25) and susceptible (Huanghuadajinyuan, HD, 36) tobacco in responding to Ralstonia solanacearum infection.
PubMed News (NIH) 04/20/2019
Contributors : Sarika Saraswati ; Pampee Young Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. RNA sequencing was performed on uninjured, and injured (FSP1, and aSMA expressing) fibroblasts from mice hearts. Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis as well as physiological repair, making them a difficult therapeutic target. Fibroblasts are a heterogeneous cell population lacking unique functional classification. We demonstrated that FSP1 and αSMA expressing cells are distinct, post-injury fibroblasts in the heart, kidney, and skin and exhibit unique temporal expression
PubMed News (NIH) 04/20/2019
Contributors : Masaya Baba ; Mitsuko Furuya ; Takanobu Motoshima ; Martin Lang ; Shintaro Funasaki ; Wenjuan Ma ; Hong-Wei Sun ; Hisashi Hasumi ; Ying Huang ; Ikuma Kato ; Tsuyoshi Kadomatsu ; Yorifumi Satou ; Nicole Morris ; Baktiar O Karim ; Lilia Ileva ; Joseph D Kalen ; Luh Ade Wilan Krisna ; Yukiko Hasumi ; Aiko Sugiyama ; Ryoma Kurahashi ; Koshiro Nishimoto ; Masafumi Oyama ; Yoji Nagashima ; Naoto Kuroda ; Kimi Araki ; Masatoshi Eto ; Masahiro Yao ; Tomomi Kamba ; Toshio Suda ; Yuichi Oike ; Laura S Schmidt ; W M Linehan Series Type : Expression profiling by array Organism : Mus musculus. Renal Cell Carcinoma (RCC) associated with Xp11.2 translocation (TFE3-RCC) has been recently defined as a distinct subset of RCC.
PubMed News (NIH) 04/20/2019
Contributors : Min Zhang ; Jason Westin ; Zhiqiang Wang ; Larry W Kwak ; Sattva S Neelapu ; Wencai Ma ; R E Davis Series Type : Expression profiling by array Organism : Homo sapiens. Tonsil specimens were freshly obtained from children undergoing elective tonsillectomy, trimmed of adjacent mucosa and skeletal muscle, disaggregated into single-cell suspensions, and viably cryopreserved.
PubMed News (NIH) 04/20/2019
Contributors : Danielle Park ; Erik Sahai ; Stefan Boeing Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. A panel of human fibroblasts derived from patient samples (vulval, oral, cervical and breast carcinoma and metastatic melanoma) were seperated according to their ability to generate an aligned (anisotropic) or non-aligned extracellular matrix.

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