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PubMed News (NIH) 02/21/2019 23:00
Contributors : Luyi Tian ; Shian Su ; Azadeh Seidi ; Shalin H Naik ; Jafar S Jabbari ; Matt Ritchie Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Single cell RNA sequencing (scRNA-seq) technology has undergone rapid development in recent years and brings new challenges in data processing and analysis.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Wilbert Zwart ; Andre Bergman Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including cancer‐associated fibroblasts (CAFs) which play a key role in cancer development.
PubMed News (NIH) 02/21/2019 23:00
Contributor : Shuyu Zhang Series Type : Other Organism : Homo sapiens. Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of RNA. The goals of this study are to compare HuR binding RNAs between 0 or 5 Gy irradiation, and analyze its effect on RNA expression. Methods: Human skin fibroblast cell line WS1 cells were treated with 0 or 5 Gy irradiation. After 24 h, RNA expression was measured using using Illumina HiSeq4000. Meanwhile, RIP was performed using HuR antibody. HuR bound mRNAs after 0 or 5 Gy irradiation was measured using using Illumina HiSeq4000. Results: RIP-sequencing reveals HuR binding RNAs between 0 or 5 Gy irradiation in WS1 cells. RNA sequencing reveals dyeregulated RNAs between 0 and 5 Gy irra.
PubMed News (NIH) 02/21/2019 23:00
Contributors : André F Rendeiro ; Thomas Krausgruber ; Nikolaus Fortelny ; Fangwen Zhao ; Thomas Penz ; Matthias Farlik ; Linda C Schuster ; Amelie Kuchler ; Szabolcs Tasnády ; Marienn Réti ; Mátrai Zoltán ; Donat Alpar ; Csaba Bödör ; Christian Schmidl ; Christoph Bock Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Stefan Jordan ; Navpreet Tung ; Samuel Rose ; Christie Chang ; Miriam Merad Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Caloric restriction is considered to be anti-inflammatory. In this study we examined the effect of fasting on peripheral leukocyte populations. We found that short-term fasting affects metabolic and pro-inflammatory activity of monocytes and decreases numbers of circulating monocytes. For this study, we sorted hepatocytes from fed and fasted mice, monocytes from bone marrow from fed and fasted mice, and monocytes from bone marrow from wildtype and Ccr2-deficient mice.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Dong-woo Cho ; Wonil Han ; Narendra K Singh Series Type : Expression profiling by array Organism : Homo sapiens. Whole transcriptome profiling of hBMMSCs printed with various dECM bioinks were conducted to reveal the effect of compositional variations in a tissue-specific manner Differential expression patterns of genes were observed in a tissue-specific manner, and this research provides strong evidence of the tissue-specific functionalities of dECM bioinks.
PubMed News (NIH) 02/21/2019 23:00
Contributors : M J Delas ; Benjamin T Jackson ; Gregory J Hannon Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Long non-coding RNAs (lncRNAs) show patterns of tissue- and cell-type-specific expression that are very similar to those of protein coding genes and consequently have the potential to control stem and progenitor cell fate decisions along a differentiation trajectory.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Xinping Yang ; Tsu-Fan Cheng ; Zhong Chen Series Type : Expression profiling by array Organism : Homo sapiens. To investigate the regulatory mechanisms and targets of the activation of NF-𝛋B and inflammatory pathways, we treated HPV(-) head and neck cancer line UM-SCC 46 cells with TNF-a and LTB at different time points, and compared the gene expression by microarray.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Olga Tsyusko ; Daniel Starnes Series Type : Expression profiling by array Organism : Caenorhabditis elegans. Caenorhabditis elegans were exposed at EC30 for 48 hr at L1 stage to ZnSO4, pristine ZnO-MNPs, phosphate aged pZnO-MNPs and sulfidized sZnO-MNPs Whole genome whole trascript microarrays were used to examine and compare global gene expression profiles among treatments.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Li Tang ; Yong Cao ; Xueqin Song ; Xiaoyan Wang ; Yan Li ; Minglan Yu ; Mingying Li ; Xu Liu ; Fang Huang ; Feng Chen ; Haisu Wan Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. HOXC6 is a member of the HOX family, and its aberrant expression has been verified in a variety of cancers, such as prostate, breast,nasopharyngeal carcinoma,gastric, and ovarian cancers.Some studies suggest that HOXC6 might be involved in tumor initiation and progression.However, the role of HOXC6 in esophageal squamous cell carcinoma cells has not been fully investigated.Here we study how HOXC6 affects the malignant phenotype of esophageal squamous cell carcinoma cells.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Kristoffer Rigbolt ; Jens C Nielsen Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of conditions ranging from simple steatosis (NAFL), over non-alcoholic steatohepatitis (NASH) with or without fibrosis, to cirrhosis with end-stage disease.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Martin Falk ; Yana Feodorova ; Natasha Naumova ; Maxim Imakaev ; Bryan Lajoie ; Heinrich Leonhardt ; Boris Joffe ; Job Dekker ; Fudenberg Geoffrey ; Irina Solovei ; Mirny Leonid Series Type : Other Organism : Mus musculus. The mammalian cell nucleus displays a remarkable spatial segregation of active euchromatic from inactive heterochromatic genomic regions.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Karlheinz Holzmann ; Sarah Gul ; Pavel Strnad ; Yoshiaki Sunami ; Thomas Wirth Series Type : Expression profiling by array Organism : Mus musculus. Activation of hepatic FoxO3 signaling induces hyperglycemia and hyperinsulinemia. Metformin administration reverses FoxO3-induced phenotype development. To investigate the underlying mechanism, we used microarrays to detail the global programme of gene expression which is regulated by hepatic FoxO3 signaling.
PubMed News (NIH) 02/21/2019 23:00
Contributors : Franziska Hentzschel ; Sabine Fraschka ; Richard Bartfái ; Ann-Kristin Mueller ; Dirk Grimm Series Type : Expression profiling by high throughput sequencing Organism : Plasmodium berghei. To introduce a non-canonical RNA interference pathway into Plasmodium berghei (P. berghei), we generated a P. berghei line constitutively expressing the human protein Argonaute 2 (Ago2) and episomally expressed Ago2-dependent short hairpin RNAs (AgoshRNAs) against GFP.

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