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Annals of Internal Medicine 10/14/2019 17:45
Background:. The large observed variability in hemophilia prevalence prevents robust estimation of burden of disease. Objective:. To estimate the prevalence and prevalence at birth of hemophilia and the associated life expectancy disadvantage. Design:. Random-effects meta-analysis of registry data. Setting:. Australia, Canada, France, Italy, New Zealand, and the United Kingdom. Participants:. Male patients with hemophilia A or B. Measurements:. Prevalence of hemophilia as a proportion of cases to the male population, prevalence of hemophilia at birth as a proportion of cases to live male births by year of birth, life expectancy disadvantage as a 1 − ratio of prevalence to prevalence at birth, and expected number of patients worldwide based on pre.
Annals of Internal Medicine 10/14/2019 17:45
Background:. Whether health care provider burnout contributes to lower quality of patient care is unclear. Purpose:. To estimate the overall relationship between burnout and quality of care and to evaluate whether published studies provide exaggerated estimates of this relationship. Data Sources:. MEDLINE, PsycINFO, Health and Psychosocial Instruments (EBSCO), Mental Measurements Yearbook (EBSCO), EMBASE (Elsevier), and Web of Science (Clarivate Analytics), with no language restrictions, from inception through 28 May 2019. Study Selection:. Peer-reviewed publications, in any language, quantifying health care provider burnout in relation to quality of patient care. Data Extraction:. 2 reviewers independently selected studies, extracted measures o.
Annals of Internal Medicine 10/14/2019 17:45
Background:. Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity. Objective:. To determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations of sepsis. Design:. Patient-level, single-group, diagnostic study.
Annals of Internal Medicine 10/14/2019 17:45
Internists and other physicians may be asked to participate in research studies that include genomic screening of their patients. Because genomic studies can identify many variants with potential clinical or personal implications, physicians should carefully consider the effect of participation on their patients, as well as the time and effort needed for the physicians to interpret the results and decide how best to use the information. Among the questions they will need to explore is whether testing will be done in a laboratory that is certified under the Clinical Laboratory Improvement Amendments and authorized to generate results for clinical purposes. Physicians should also determine which results will be returned and how these results

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