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Annals of Internal Medicine 05/04/2020 17:44
State-based medical license applications often ask about mental health diagnoses and treatment in terms that stigmatize mental illness, which inadvertently discourages physicians from seeking care. In this article, the authors describe a recent collaboration that resulted in updated and destigmatized language on their state's medical license application.
Annals of Internal Medicine 05/04/2020 17:44
Background:. A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in China in December 2019. There is limited support for many of its key epidemiologic features, including the incubation period for clinical disease (coronavirus disease 2019 [COVID-19]), which has important implications for surveillance and control activities. Objective:. To estimate the length of the incubation period of COVID-19 and describe its public health implications. Design:. Pooled analysis of confirmed COVID-19 cases reported between 4 January 2020 and 24 February 2020. Setting:. News reports and press releases from 50 provinces, regions, and countries outside Wuhan, Hubei province, China. Participants:. Persons with co.
Annals of Internal Medicine 05/04/2020 17:44
The Parkinson Study Group STEADY-PD III Investigators reported the results of a randomized controlled trial evaluating the effect of isradipine, a dihydropyridine calcium-channel blocker, on clinical progression of Parkinson disease. The editorialists discuss the findings and the need for more reliable in vivo biomarkers of Parkinson disease progression and measures of specific target engagement.
Annals of Internal Medicine 05/04/2020 17:44
Walensky and colleagues' cost-effectiveness analysis estimated the potential clinical benefits of tenofovir alafenamide–emtricitabine (F/TAF) and the resultant cost savings of lower risk for renal failure and fractures versus the increased cost of branded F/TAF compared with generic tenofovir disoproxil fumarate–emtricitabine for HIV preexposure prophylaxis (PrEP).
Annals of Internal Medicine 05/04/2020 17:44
Background:. Studies suggest that dihydropyridine calcium-channel blockers may be associated with reduced risk for Parkinson disease (PD). Objective:. To assess the effect of isradipine, a dihydropyridine calcium-channel blocker, on the rate of clinical progression of PD. Design:. Multicenter, randomized, parallel-group, double-blind, placebo-controlled trial.
Annals of Internal Medicine 05/04/2020 17:44
Background:. Tenofovir alafenamide–emtricitabine (F/TAF) was recently approved as a noninferior and potentially safer option than tenofovir disoproxil fumarate–emtricitabine (F/TDF) for HIV preexposure prophylaxis (PrEP) in the United States. Objective:. To estimate the greatest possible clinical benefits and economic savings attributable to the improved safety profile of F/TAF and the maximum price payers should be willing to pay for F/TAF over generic F/TDF. Design:. Cost-effectiveness analysis. Data Sources:. Published literature on F/TDF safety (in persons with and those without HIV) and the cost and quality-of-life effects of fractures and end-stage renal disease (ESRD). Target Population:. Age-stratified U.S. men who have sex with men (MSM.

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