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Pharmaceutical Microbiology 11/13/2019 07:00
Here is my article on digital transformation of pharmaceuticals - "Becoming Pharma 4.0: How Digital Transformation Is Reshaping Pharmaceuticals". The digital transformation of biopharmaceutical manufacturing is continuing at a rapid pace as companies attempt to mine the sources of data available. Innovations include predictive analytics, big data analytics, and creating the digital plant. Digital transformation offers a mechanism to revise its business model, to improve production processes, to design new drugs faster by using artificial intelligence to screen compounds and to increase responsiveness to customers. Furthermore, the volume of data processed by pharmaceutical firms shows no sign of slowing down. This means pharmaceutical compa.
Pharmaceutical Microbiology 11/12/2019 07:00
Wound inflammation which results in impaired wound healing can have serious consequences for patients. Researchers from Charité -- Universitätsmedizin Berlin have discovered a new defensive mechanism which enables our skin to actively kill bacteria. Central to this mechanism is a cellular messenger molecule known as 'interleukin 6', whose mode of action may be used in the future to prevent wound infections. Skin wound colonization by bacteria or other pathogens can lead to severe inflammation. In the worst cases, this can result in septicemia or amputation. Prompt treatment is therefore essential. However, growing numbers of bacteria developing antibiotic resistance have resulted in treatment options becoming increasingly limited. The. that
Pharmaceutical Microbiology 11/11/2019 07:00
The concept of quality is central to the delivery of laboratory services and this is achieved through the incorporation of quality systems, quality control and quality assurance in all aspects of laboratory practice. Essential to all aspects of laboratory results is to ensure that they are accurate, reliable and delivered in a timely fashion. To ensure that these requirements are in place and that they are consistently being met, audits should be regularly undertaken. Quality audits play an essential role in the Quality Management System and these are typically a systematic examination of a system, discrete operate, product or process. In pharmaceuticals and healthcare, the analytical laboratory function plays an important role in testing p.
Pharmaceutical Microbiology 11/10/2019 08:00
Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of "ammunition" because of more and more frequently occurring resistances. Scientists from the Technical University of Munich and the Max Planck Institute of Molecular Physiology has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins in bacteria. ; approximately 33,000 of them die. Despite this enormous and globally increasing danger, very few new antibiotics have been developed and approved in the past few decades. There is no improvement in sight. That is why it is urgently necessary to find n.
Pharmaceutical Microbiology 11/09/2019 07:00
Researchers have captured images of the formation of individual viruses, offering a real-time view into the kinetics of viral assembly. The research provides new insights into how to fight viruses and engineer self-assembling particles. "Structural biology has been able to resolve the structure of viruses with amazing resolution, down to every atom in every protein," said Vinothan Manoharan, the Wagner Family Professor of Chemical Engineering and Professor of Physics at the Harvard John A. Paulson School of Engineering and Applied Sciences. "But we still didn't know how that structure assembles itself. Our technique gives the first window into how viruses assemble and reveals the kinetics and pathways in quantitative detail.". , the most abu.
Pharmaceutical Microbiology 11/08/2019 07:00
A 5-minute soak in a 40% solution of household bleach decontaminated stainless steel wires coated with chronic wasting disease (CWD) prions, according to a new study by National Institutes of Health scientists. The scientists used the wires to model knives and saws that hunters and meat processors use when handling deer, elk and moose -- all of which are susceptible to CWD. The research was conducted at Rocky Mountain Laboratories (RML) in Hamilton, Mont., USA. , members of the deer family. To date CWD has never been found in people. However, other prion diseases can affect people, therefore scientists, wildlife managers and public health agencies have suggested handling CWD cervid tissues with caution. CWD is spreading in North America, in.
Pharmaceutical Microbiology 11/07/2019 07:30
An emerging, novel approach to control antibiotic-resistant bacterial infections is based on the use of light, in (400–470 nm). A new research paper of interest, concerning biofilm elimination by inducing oxidative stress. Here s the abstract:. Resolution of bacterial infections is often hampered by both resistance to conventional antibiotic therapy and hiding of bacterial cells inside biofilms, warranting the development of innovative therapeutic strategies. Here, we report the efficacy of blue laser light in eradicating. Pseudomonas aeruginosa. cells, grown in planktonic state, agar plates and mature biofilms, both in vitro and in vivo, with minimal toxicity to mammalian cells and tissues. Results obtained using knock-out mutants point to ox.
Pharmaceutical Microbiology 11/06/2019 07:30
Two European disinfectant test standards have been updated this year. EN 1276: 2019 Phase 2 / Step 1 – Quantitative Bactericidal Suspension Test. This involves at least two Gram-positive bacteria ( Staphylococcus aureus and Enterococcus hirae ) and at least two Gram-negative organisms ( Pseudomonas aeruginosa and Escherichia coli ), with the provision for additional test organisms if desired. Incorporated into the test procedure are interfering substances to simulate clean and dirty conditions using different levels of Bovine Serum Albumin (BSA) and the effect of water hardness.
Pharmaceutical Microbiology 11/04/2019 11:49
New research shows that protein-based biosensors can detect the presence of a desired enzyme target and respond by physically lighting up and enabling researchers to immediately identify cells with increased overall enzyme yield. The new approach, which comes from Los Alamos National Laboratory, can be translated to screening of metagenomic samples, rational enzyme design, or. directed evolution of known enzymes.
Pharmaceutical Microbiology 11/03/2019 13:14
An excellent new two-volume book has been published, vital for those working in pharmaceuticals and healthcare:. Good Distribution Practice: A Handbook for Healthcare Manufacturers and Suppliers - Edited by Siegfried Schmitt . A two-volume reference publication, discussing in detail global regulations and practices. Over 30 professionals and experts share their knowledge, interpret the regulations and provide a plethora of best-practice examples. Volume 1. Following an introduction into the subject of Good Distribution Practice (GDP), the key topics covered in this volume relate to:. The applicable GDP regulations globally, including serialization. Qualified Person (QP) and Responsible Person (RP) in GDP. GDP as part of the Quality Management Sy.
Pharmaceutical Microbiology 11/03/2019 04:30
Researchers have demonstrated a new strategy in fighting antibiotics resistance: the use of artificial haem proteins as a Trojan horse to selectively deliver antimicrobials to target bacteria, enabling their specific and effective sterilization. The technique killed 99.9% of Pseudomonas aeruginosa, a potentially deadly, antibiotic-resistant bacterium present in hospitals. The strategy should also work for other dangerous bacteria. Pseudomonas aeruginosa is a dangerous bacterium that causes infections in hospital settings and in people with weakened immune systems. It can cause blood infections and pneumonia, while severe infections can be deadly. Highly resistant to antibiotic treatment, P. aeruginosa is one of the most critical pathogens u.
Pharmaceutical Microbiology 11/02/2019 07:00
Non-alcoholic fatty liver disease (NAFLD) is the build-up of fat in the liver due to factors other than alcohol. It affects about a quarter of the adult population globally, but its cause remains unknown. Now, researchers have linked NAFLD to gut bacteria that produce a large amount of alcohol in the body, finding these bacteria in over 60% of non-alcoholic fatty liver patients. Researchers discovered the link between gut bacteria and NAFLD when they encountered a patient with severe liver damage and a rare condition called auto-brewery syndrome (ABS). Patients with ABS would become drunk after eating alcohol-free and high-sugar food. The condition has been associated with yeast infection, which can produce alcohol in the gut and lead to in.
Pharmaceutical Microbiology 11/01/2019 08:30
Findings from an innovative new study led by researchers at Dartmouth's Geisel School of Medicine and published this week in Nature Microbiology reveal that the way in which human fungal pathogens form colonies can significantly impact their ability to cause disease. Highly diverse and adaptable, these colonies, known as biofilms, allow invasive fungal pathogens such as Aspergillus fumigatus to grow and thrive, infecting the lungs of patients, even under demanding environmental circumstances. the researchers sought to assess how an important environmental stressor impacts disease progression in invasive aspergillosis, a disease caused by the mold Aspergillus fumigatus, and to identify fungal genetic factors involved in this process. The res.
Pharmaceutical Microbiology 10/31/2019 10:00
Compliance is an affirmative indication or judgement that the supplier of a product or service has met the requirements of the relevant specifications, contract or regulation; also the state of meeting the requirements. Compliance is something that meets both the text and the spirit of a requirement. This is the central message of the book Audit and Control for Healthcare Manufacturers” by Tim and Jennifer Sandle (published by DHI, http://www. Posted by Dr. Tim Sandle, Pharmaceutical Microbiology. Pharmaceutical Microbiology © Dr Tim Sandle.
Pharmaceutical Microbiology 10/30/2019 08:00
The healthcare industry is experiencing rapid change as a result of new technologies. With physical therapy being one field that is seeing some of the most significant changes, patient care is getting more efficient and more effective. We now see robotics becoming more common in a physical therapy setting, and patients can now use a range of tools that can be accessed from a smartphone or tablet. The technological tools are enabling and other states across the nation. These advancements will provide patients with improved outcomes and physical therapy professionals will be able to achieve better results in less time. With the latest tech on the horizon, patients and physical therapists can expect a much brighter future for rehabilitation se.
Pharmaceutical Microbiology 10/29/2019 09:30
A new study, published today in eLife. The findings in mice reveal how mucosal infections, specifically bladder infections, can rewire inflammatory responses driven by a protein called tumour necrosis factor-alpha (TNFɑ) to impact susceptibility to recurrence. These results could inform the development of more effective new treatment strategies. Scientists have shed new light on how mucosal infections can affect the body’s inflammatory response to shape susceptibility to recurrence. Their study in mice reveals how recurrent mucosal infections, specifically bladder infections, can rewire inflammatory responses driven by a protein called tumour necrosis factor-alpha (TNFɑ) to impact susceptibility. The findings, published in eLife, could info.
Pharmaceutical Microbiology 10/28/2019 08:00
A new book has been published – “Biocontamination Control for Pharmaceuticals and Healthcare” by written Tim Sandle. The book outlines a biocontamination strategy that tracks bio-burden control and reduction at each transition in classified areas of a facility. This key part of controlling risk escalation can lead to the contamination of medicinal products, hence necessary tracking precautions are essential. Regulatory authorities have challenged pharmaceutical companies, healthcare providers, and those in manufacturing practice to adopt a holistic approach to contamination control. New technologies are needed to introduce barriers between personnel and the environment, and to provide a rapid and more accurate assessment of risk. This book
Pharmaceutical Microbiology 10/27/2019 06:15
A new study from EPFL scientists has found that bacteria use mechanical forces to divide, along with biological factors. The research, led by the groups of John McKinney and Georg Fantner at EPFL, came after recent studies suggested that bacterial division is not only governed by biology, but also by physics. However, this interplay is poorly understood. Most bacteria are rod-shaped cells that multiply by doubling their length and dividing in the middle to yield two "daughter cells." Mechanisms that control these processes in space and time are critical for survival. The importance of these mechanisms becomes even clearer, given how pervasive bacteria are in everyday life, and how ubiquitous their use is in biotechnology. The scientists stu.
Pharmaceutical Microbiology 10/26/2019 07:00
, Acinetobacter baumannii, for which new antibiotics are urgently needed is one step closer to being tackled, as researchers from the Department of Chemistry -- University of Warwick have made a breakthrough in understanding the enzymes that assemble the antibiotic enacyloxin. Acinetobacter baumannii is a pathogen that causes hospital-acquired infections that are very difficult to treat, because they are resistant to most currently available antibiotics. In a previous paper, researchers at the University of Warwick and Cardiff University showed that a molecule called enacyloxin is effective against Acinetobacter baumannii.

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