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New insights into why a faulty gene involved in a devastating form of a kidney condition called nephrotic syndrome leads to disease in some patients have been identified in new Kidney Research UK-funded research led by the University of Bristol. The findings, published in the Journal of the American Society of Nephrology (JASN), could pave the way for new ways to prevent or treat the condition, by revealing new targets to intervene in the process. Around 1 in 50,000 children are diagnosed with nephrotic syndrome each year.
A biologist at Worcester Polytechnic Institute (WPI) has shown that a key biological component in a worm's communication system can be repurposed to take on a different job, a critical finding about the workings of evolution that could one day affect research into drug interactions, agricultural bio-engineering, and a better understanding of genetic inheritance through multiple generations.
Researchers have developed a guide to help labs standardize the production of mature hepatic-like cells (HPCs) from stem cells and easily compare gene expression of HPCs to actual human liver tissue. This moderately high throughput protocol can enable a relatively quick assessment of the efficacy of stem cell differentiation and help guide the optimization of differentiation conditions in regenerative medicine applications. The protocol and its implications are published in Stem Cells and Development.
Pulmonary embolism is a potentially life-threatening condition, in which blood clots migrate to arteries in the lungs, with the risk for increased pressure on the right side of the heart, impaired breathing, and even death. Yale researchers recently studied trends in hospitalization and mortality rates for people with pulmonary embolism, and their findings could help improve care for these patients.
Materials scientists widely incorporate hydroxyapatite (HA) for bone repair in bone tissue engineering (BTE) due to its superior biocompatibility as a natural component of human bones and teeth. In a recent report on Science Advances, a research team highlighted the proliferation-suppressive effect of HA nanoparticles (n-HA) against a variety of cancer cells by combining the translational value of n-HA as a bone-regenerating material and an anti-tumor agent. In the study, Kun Zhang and an interdisciplinary research team in the departments of Orthopedic Surgery, Dermatology, Biomedical Metal Materials and the National Engineering Research Center for Biomaterials in China, demonstrated the inhibition of tumor growth, metastasis prevention and.
Getting treatment for a serious injury or ailment isn't simply a matter of taking prescribed medication or showing up for appointments on time. It's also about the little things in between—dealing with complicated billing or insurance processes, for example, or navigating the mental toll of a physical disability that affects quality of life.
Researchers have developed a simple, fast, and standardized method for measuring phage virulence quantitatively, which can expediate phage therapy development by allowing robust individual and combined testing of phage efficacy. The method, which takes into account all factors affecting virulence, is published in a preview issue of PHAGE: Therapy, Applications, and Research, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers launching in early 2020.

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