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The same genes that greatly increase the risk of breast cancer in U.S. white women, including women of Ashkenazi Jewish descent, also greatly increase breast cancer risk among African American women. These genes include the BRCA1, BRCA2 and PALB2 genes, each of which was associated with a more than seven-fold risk of breast cancer, as well as four other genes associated with a more moderate increase in risk. Previous studies of women of African ancestry were too small to assess genes other than BRCA1 and BRCA2.
A team of researchers from Stanford University in the U.S. and Southern University of Science and Technology in China has found evidence that suggests metastasis of cancerous tumors may get its start much earlier than previously thought. In their paper published in the journal Nature Genetics, the group describes their whole-exome sequencing analysis of multiple types of tumors that resulted from metastasis and what they learned about it.
The expansion of 'mutant' cells that could lead to cancer is often kept in check by their neighbours, research from the Wellcome Sanger Institute, the University of Cambridge and their collaborators has found. The team discovered that when equally-matched cells in the oesophagus of mice coincided, they acted as a brake on one another's growth.
A tissue bioengineering product based on patient cells that have been corrected using genomic editing has been designated as an orphan drug by the European Medicines Agency (EMA) for the treatment of Recessive Dystrophic Epidermolysis Bullosa. The condition, known as Butterfly's Skin, is characterised by the appearance of fragile skin and mucosal epithelium, ulcers and aggressive skin carcinomas. The work carried out to obtain this designation, sponsored by the Centre for Biomedical Research Network of Rare Diseases (CIBERER, in its Spanish acronym), was coordinated by Fernando Larcher.
A team of researchers affiliated with several institutions in Japan has found an increased risk of gastric cancer in East Asian people who have a certain gene mutation and who also have certain drinking habits. In their paper published in the journal Science Advances, the group describes their comparison of genetic data from hundreds of people with gastric cancers and what they learned about it.
An analysis of 13,000 tumors highlights two previously overlooked genes as potential new therapeutic targets for cancer treatment. The researchers have also identified potential new therapeutic targets for male infertility. Both findings are the result of the most comprehensive evolutionary analysis of RNA modification proteins to date, published today in the journal Genome Biology.
A small piece of genetic material could hold the key to diagnosing and treating high blood pressure earlier, according to new research by scientists at the University of Glasgow, who found that a small piece of genetic material could explain why arteries become increasingly stiff (which happens in high blood pressure) and why blood vessels age faster.
According to Statistics Austria about 5,600 men are diagnosed with prostate cancer in Austria every year, meaning it accounts for roughly a quarter of all cancers in men. For some the cancer develops slowly and requires minimal treatment, but others have aggressive forms of the disease which progress very quickly. In order to be able to treat prostate cancer more effectively, better understanding of the complex mechanisms that occur at the molecular level within the tumor is needed. In 2015, a team led by molecular pathologist Lukas Kenner of MedUni Vienna made the unexpected discovery that the protein STAT3 plays a tumor-suppressing role in prostate cancer using a mouse model. They showed that the progression of the disease was significant.

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