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Fight Aging! 01/20/2020 06:22
Myelin is the sheathing of nerves, essential to their function. Excessive loss produces disabling and ultimately fatal conditions such as multiple sclerosis, but we all lose myelin integrity to some degree as a consequence of the damage and dysfunction of degenerative aging. This most likely contributes to cognitive decline and other age-related issues. A number of different approaches have been identified to boost the operation of the normal maintainance processes that remyelinate nerves, such as FGF21 upregulation, or increasing the size of remyelinating cell populations. Here, researchers discover another possible trigger that might force greater remyelination. While the work aims at treatment of conditions such as multiple sclerosis, su.
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(MENAFN - The Expresswire) Global Biobanks Market 2019 | Prominent Factors by Industry Size, Share, Business Development Plans, Market Dynamics and Fo...
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BIOENGINEER.ORG 01/16/2020 12:48
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association January 2020 Journal Digest Credit: Credit Alzheimer’s Association CHICAGO, January 16, 2020 – A sleep medication already approved to treat insomnia in the general population may also be beneficial for individuals with Alzheimer’s, according to a new study published online today by Alzheimer’s & Dementia: The [...]
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SynBioBeta 01/16/2020 09:32
Next-generation gene editing system has applications in development of cell and gene therapies Base editing builds on CRISPR offering and will expand Horizon’s research tools and services Horizon seeks partners to assess and shape platform development January 14, 2020 03:22 AM Eastern Standard Time CAMBRIDGE, England–(BUSINESS WIRE)–Horizon Discovery Group plc (LSE: HZD) ("Horizon", "the Company" [...]. .
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Scientific American 01/16/2020 08:00
For years, researchers had wondered how beta-amyloid and tau were connected, says Rudolph Tanzi, an expert on the molecular genetics of Alzheimer’s disease at Massachusetts General Hospital, who was not involved in the new research.
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The Department of Commerce (Commerce) preliminarily determines that PT. Cheil Jedang Indonesia (CJ Indonesia), the sole producer or exporter subject to this administrative review, did not make sales below normal value of monosodium glutamate (MSG) from the Republic of Indonesia (Indonesia) during the period of review (POR), November 1, 2017 through October 31, 2018. We invite interested parties to comment on these preliminary results.
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GlobeNewswire 01/15/2020 06:30
Leader in clinical research for Alzheimer’s, Parkinson’s and other misfolded protein diseases joins advisory board of global leaders in neurodegenerative diseases. Leader in clinical research for Alzheimer’s, Parkinson’s and other misfolded protein diseases joins advisory board of global leaders in neurodegenerative diseases.
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PR Newswire 01/14/2020 19:00
SAN FRANCISCO, Jan. 14, 2020 /PRNewswire/ -- Gladstone researchers, in collaboration with Genentech, a member of the Roche group, have shown therapeutic efficacy of a new experimental drug in mouse models of Alzheimer's disease and a rare genetic form of epilepsy known as Dravet syndrome....
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FeedNavigator (EU) 01/14/2020 05:07
Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease. ApoE is commonly found in amyloid deposits of different origins, and its interaction with amyloid-β peptide (Aβ), the hallmark of AD, is well known. However, studies on the interaction of ApoEs with other amyloid-forming proteins are limited. Islet amyloid polypeptide (IAPP) is an amyloid-forming peptide linked to the development of type-2 diabetes and has also been shown to be involved in AD pathology and vascular dementia. Here we studied the impact of ApoE on IAPP aggregation and IAPP-induced toxicity on blood vessel pericytes. Us.
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PubMed News (NIH) 01/13/2020 23:00
We conclude that genetic risk of AD functionally translates into different microglia pathway responses to Aβ pathology, placing AD genetic risk downstream of the amyloid pathway but upstream of TAU pathology.
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NASDAQ 01/11/2020 07:00
Despite a strong year for biotechnology stocks, Biogen (NASDAQ: BIIB) and Gilead Sciences (NASDAQ: GILD) both underwhelmed investors in 2019. Biogen's shares ended the year down 1.4%, whereas Gilead's stock eked out a modest gain of 3.88%. By contrast, the biotech funds iShares.
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The paper does not report the ApoE genotype of these participants, but ApoE4 has long been known to accelerate amyloid AD pathology and lead to earlier onset.
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Healio News 01/10/2020 12:35
No sleep for one night increased levels of the Alzheimer’s disease biomarker tau among young, healthy men, according to results of a two-condition crossover study published in Neurology. “Based on the emerging line of data, it is becoming clearer that sleep may be an important lifestyle factor that modulates the prospective risk of Alzheimer's disease,” Jonathan Cedernaes, MD, PhD, of the department of neuroscience at Uppsala University in Sweden, told Healio Psychiatry. “Sleep problems in middle age have also been associated with an increased risk of later developing.
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