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PubMed News (NIH) 09/16/2019
Contributors : Christoph Gericke ; Anna Mallone ; Britta Engelhardt ; Roger M Nitsch ; Maria T Ferretti Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. The goal of this study is to investigate the involvement of inflammation in Alzheimer’s disease (AD) and to clarify the signaling pathways involved in the presence of beta-amyloidosis, a hallmark of AD pathogenesis, to help identifying potential targets for therapy.
PubMed News (NIH) 09/11/2019
Contributors : Shunzo Ikarashi ; Atsunori Tuchiya ; Shuji Terai Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Background: Mesenchymal stem cells (MSCs) can be acquired from medical waste. MSCs are easily expanded and have multiple functions, including anti-inflammatory effects. We evaluated the effects of human adipose tissue-derived MSCs (AD-MSCs) and umbilical cord tissue-derived MSCs (UC-MSC) in a dextran sulfate sodium (DSS)-induced mouse model. Methods: Human AD-MSCs and UC-MSCs (1 × 106 cells) were injected intravenously into a 7-day DSS-induced colitis model. The therapeutic effects of cell origin, injection timing, and supernatants obtained from MSC cultures were evaluated. We also analyzed.
PubMed News (NIH) 07/18/2019
Contributors : Ana B Pavel ; Teresa Song ; Hyun J Kim ; Del D Ester ; James G Krueger ; Celina Dubin ; Xiangyu Peng ; Hui Xu ; Ning Zhang ; Yeriel Estrada ; Louis Denis ; Niranjan Rao ; Sandeep Gupta ; David Zammit ; Robert Bissonnette ; Emma Guttman-Yassky Series Type : Expression profiling by array Organism : Homo sapiens. We conducted a randomized, double-blind, placebo-controlled trial in adults with moderate-to-severe AD to test the efficacy of JAK/SYK-inhibitor ASN002.

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