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PubMed News (NIH) 02/23/2020 23:00
Contributors : Nicolai van Oers ; Fatma Coskun Series Type : Non-coding RNA profiling by high throughput sequencing Organism : Homo sapiens ; Mycobacterium tuberculosis. The purpose of this study was to identify Mtb- and hsa-encoded miRNAs produced in infected macrophages.
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In Mycobacterium tuberculosis, mycolic acids and their glycerol, glucose, and trehalose esters (“cord factor”) form the main part of the mycomembrane.
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FeedNavigator (EU) 02/15/2020 11:12
An association between glycine and insulin levels is observed in patients with pulmonary tuberculosis and type 2 diabetes.
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European Respiratory Journal 02/14/2020 06:10
Bedaquiline is a highly effective drug for tuberculosis (TB) and is an important part of current regimens for drug-resistant TB. Bedaquiline resistance is rarely tested in operational settings. In a prospective cohort of 292 patients with drug-resistant TB and HIV starting bedaquiline in KwaZulu-Natal, South Africa, we whole genome sequenced isolates from 92 baseline culture positive patients. Five patients were infected with strains harbouring mutations associated with bedaquiline resistance, and an additional five acquired resistance mutations during treatment. Among the baseline culture positive patients, those with baseline or acquired resistance mutations had substantially worse clinical outcomes compared to patients without. Given the.
More from European Respiratory Journal:
Novel Approach for Transdermal Delivery of Rifampicin to Induce Synergistic Antimycobacterial Effects Against Cutaneous and Systemic Tuberculosis Using a Cationic Nanoemulsion Gel.
More from International Journal of COPD: 01/24/2020 12:00
Condition : Tuberculosis Interventions : Biological: Low-dose freeze-dried recombinant tuberculosis vaccine (AEC / BC02); Biological: Low-dose adjuvant for freeze-dried recombinant tuberculosis vaccine (AEC / BC02); Biological: Lyophilized recombinant tuberculosis vaccine (AEC / BC02) placebo Sponsor : Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd. Not yet recruiting.
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eHealthNews.EU Portal (EU) 12/19/2019 04:00
Is it possible to screen thousands of people for tuberculosis using artificial intelligence in a country where internet barely exists? It is with CAD4TB. As of October, this innovative software is used to screen people for TB in even the remotest areas of Eritrea. It has been developed by Dutch company Thirona in collaboration with the also Dutch Delft Imaging Systems.
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