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ENDPOINTS 09/27/2019 14:29
BARCELONA — Bristol-Myers Squibb’s Opdivo couldn’t quite beat Nexavar, the standard of care in hepatocellular carcinoma, in its Phase III head-to-head. But investigators are still hoping that it can play a role in the frontline setting of this disease. Thomas Yau of the University of Hong Kong, who led the study, hit hard on Opdivo’s “clinically meaningful” advantages over the entrenched therapy, particularly in terms of side effects and quality of life. Thomas Yau. Presenting at the 2019 Congress of the European Society of Medical Oncology, Yau readily conceded that the difference in overall survival — 16.4 months on Opdivo and 14.7 months for Nexavar — did not meet statistical significance (p=0.075). Yet he also suggested that the availabi.
ENDPOINTS 08/28/2019 10:03
Less than a year after the FDA cleared Bristol-Myers Squibb and AbbVie’s approved Empliciti injection for intravenous use in combination with Celgene’s pomalidomide (Pomalyst, or Imnovid, depending on which side of the Atlantic you are) and the steroid dexamethasone for relapsed, refractory multiple myeloma, the European Commission . The approval is based on data from the 117 patient-ELOQUENT-3 trial in which the triplet doubled both median progression-free survival (PFS) and overall response rate (ORR) among patients with relapsed and refractory multiple myeloma, versus pomalidomide and low-dose dexamethasone alone. Updated trial data — with a minimum follow-up of 18.3 months — were presented at the European Hematology Association (EHA) th.

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