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PubMed News (NIH) 02/05/2020 23:00
Contributors : Sofia Fazio ; Gabriele Berti ; Francesco Russo ; Monica Evangelista ; Romina D'Aurizio ; Alberto Mercatanti ; Marco Pellegrini ; Milena Rizzo Series Type : Other Organism : Homo sapiens. miR-28-5p is downregulated in some tumor tissues in which it has been demonstrated to have a tumor suppressor (TS) activity.
PubMed News (NIH) 01/31/2020 23:00
Contributors : Kyoung-Hwa Lee ; Cheol Kwak Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We established an enzalutamide-resistant C4-2b prostate cell line that has an active androgen receptor by maintaining the C4-2b cell line in serially increasing concentrations of enzalutamide.
PubMed News (NIH) 01/30/2020 23:00
Contributors : Yuxiang Fang ; Yanqing Wang Series Type : Non-coding RNA profiling by high throughput sequencing Organism : Homo sapiens. Purpose: The goals of this study are to compare the serum extracellular vesicle (EV) delivered miRNA levels of patients with bone-metastatic prostate cancer (PCa), non-bone -metastatic PCa and benign prostatic hyperplasia (BPH), and to identify EV-delivered microRNAs in patient’s serum as indicators for bone-metastatic PCa.
PubMed News (NIH) 01/30/2020 23:00
Contributors : Yuxiang Fang ; Yanqing Wang Series Type : Non-coding RNA profiling by array Organism : Homo sapiens. Purpose: The goals of this study are to compare the serum extracellular vesicle (EV) delivered miRNA levels of patients with bone-metastatic prostate cancer (PCa), non-bone -metastatic PCa and benign prostatic hyperplasia (BPH), and to identify EV-delivered microRNAs in patient’s serum as indicators for bone-metastatic PCa.
PubMed News (NIH) 01/23/2020 23:00
Contributors : Kui Lin ; Anneleen Daemen Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Goal: Study resistance mechanisms to ATP-competitive vs. allosteric AKT inhibitors, in prostate cancer Methods: RNA-sequencing Results: Resistance to the ATP-competitive inhibitor GDC-0068 was driven by compensatory activity of parallel signaling pathways.
PubMed News (NIH) 01/20/2020 23:00
Contributors : Sandi Chiranjeevi ; Messie Charlie ; Antonio Ramos-Montoya ; Sérgio L Felisbino ; Davies Barry ; Pacey Simon Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Purpose: RNA sequence analysis identified active proliferation of T cells in the combination therapy Methods: Pten-null tumours were collected 4 hours after the last dose (18th day).
PubMed News (NIH) 01/15/2020 23:00
Contributors : Karen E Knudsen ; Jennifer J McCann Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. The deubiquitinase USP22 is a member of the SAGA transcriptional activation complex. This study used models of USP22 overexpression and depletion to identify differentially expressed gene networks.
PubMed News (NIH) 12/30/2019 23:00
Contributors : Einari A Niskanen ; Joanna K Lempiäinen ; Marjo Malinen ; Jorma J Palvimo Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. To analyze the role of BCOR (BCL6 corepressor) in androgen signaling, we used ChIP-seq to analyze chromatin binding of BCOR in androgen and vehicle treated VCaP cells.
PubMed News (NIH) 12/30/2019 23:00
Contributors : Xiaolei Shi ; Wei Zhang Series Type : Expression profiling by array Organism : Homo sapiens. To explore the gene expression signatures in human prostate cancer cells PC3 with lncAPP overexpression and knocdown, we conducted lenti viruses transfection to construct upregulation and downregulation of lncAPP in PC3 cells.
PubMed News (NIH) 12/24/2019 23:00
Contributors : Diana H Low ; Jessica S Ho Series Type : Other Organism : Homo sapiens. Cancer cells are differentially dependent on the splicing machinery compared to normal untransformed cells. The splicing machinery thus presents a potential therapeutic target in cancer. To identify splicing factors important for prostate cancer cell (PCa) growth, we performed an unbiased pooled shRNA screen in in vitro passaged cells and in vivo xenografted PCa tumors. Our screen revealed HNRNPM as a potential regulator of PCa cell growth. RNA- and eCLIP- sequencing data suggest that HNRNPM is bound to key homeostatic genes, and that loss of HNRNPM binding in a subset of these genes results in aberrant exon inclusion and exon back-splicing events in targe.

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