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PubMed News (NIH) 01/16/2019 23:00
Contributors : Lewis Chaytor ; Matthew Simcock ; Sirintra Nakjang ; Richard Heath ; Laura Walker ; Craig Robson ; Dominic Jones ; Luke Gaughan Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. To determine the impact of the Bromodomain and extra-terminal (BET) inhibitor JQ1 on the GATA2 cistrome in castrate-resistant prostate cancer we performed GATA2 ChIP-seq in the presence and absence of JQ1 and assessed differential binding upon JQ1 treatment for 24 hours.
PubMed News (NIH) 01/14/2019 23:00
Contributors : Salma Ben-Salem ; Dhirodatta Senapati ; Varadha Balaji Venkadakrishnan ; Yixue Su ; Eduardo Cortes ; Qiang Hu ; Song Liu ; Hannelore Heemers Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. To study and compare the effect of siRNA-mediated SRF or Nkx2-5 silencing on androgen-responsive genes in LNCaP cells.
PubMed News (NIH) 01/11/2019 23:00
Contributors : Lewis Chaytor ; Matthew Simcock ; Sirintra Nakjang ; Richard Heath ; Laura Walker ; Craig Robson ; Dominic Jones ; Luke Gaughan Series Type : Expression profiling by array Organism : Homo sapiens. To interrogate the extent of overlap between GATA2 and AR-V regulated transcriptomes in castrate-resistant prostate cancer cells, we assessed global gene expression changes in GATA2-depleted CWR22Rv1 cells by microarray analysis using the Illumina Human HT-12 BeadChip array and compared GATA2 regulated genes to a previously generated AR-V regulated genset (Jones et al., 2015).
PubMed News (NIH) 12/29/2018 23:00
Contributors : Vipul Bhatia ; Anjali Yadav ; Ritika Tiwari ; Shivansh Nigam ; Apul Goel ; Bushra Ateeq Series Type : Expression profiling by array Organism : Homo sapiens. SPINK1 overexpression defines the second largest subtype of prostate cancer (PCa), however molecular mechanisms underlying its upregulation remains poorly understood.
PubMed News (NIH) 12/21/2018 23:00
Contributors : Yuanjie Niu ; Zhiqun Shang ; Qian Dong ; Libin Sun ; Jianpeng Yu Series Type : Expression profiling by array Organism : Homo sapiens. To further determine the gene expression in the castration resistant condition for treating PCa, we generated and characterized an androgen-independent LNCaP-AI cell line by long-term culture of androgen-dependent LNCaP cells in RPMI-1640 medium containing charcoal-stripped serum.
PubMed News (NIH) 12/21/2018 23:00
Contributors : Qipeng Liu ; Guangyu Wang ; Qi Cao ; Kaifu Chen Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Polycomb group proteins are important epigenetic regulators for organ development, cell proliferation and differentiation, as well as initiation and progression of lethal diseases, including cancer.

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