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BioNewsFeeds 08/23/2019 10:29
Zanubrutinib received fast track designation from the FDA for people with Waldenström macroglobulinemia.
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Healio News 08/22/2019 13:57
The FDA granted priority review of the new drug application based, in part, on data from a global phase 1/phase 2 trial among patients with B-cell lymphomas and a multicenter phase 2 trial among patients with relapsed or refractory mantle cell lymphoma, in addition to safety data on 641 patients from five trials and nonclinical data.
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GlobeNewswire 08/21/2019 16:30
The NDA data package includes data from the global Phase 1/2 trial (NCT02343120) in patients with B-cell lymphomas and an aggregate of 123 patients in the multicenter Phase 2 trial of zanubrutinib in patients with relapsed or refractory (R/R) MCL in China (NCT03206970), as well as safety data on 641 patients from ...
More from GlobeNewswire: 08/20/2019 08:22
Condition : Mantle Cell Lymphoma Intervention : Sponsor : Samsung Medical Center Active, not recruiting.
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Journal of Clinical Oncology, Ahead of Print.
More from American Society of Clinical Oncolgy (ASCO):
Purpose:. The oral proteasome inhibitor oprozomib has shown preclinical antitumor activity. Here, we report phase Ib/II study results investigating single-agent oprozomib in patients with relapsed multiple myeloma and Waldenström macroglobulinemia. Patients and Methods:. The primary objectives were to determine the MTD, safety, and tolerability of oprozomib (phase Ib) as well as overall response rate (ORR; phase II). Oprozomib was administered once daily on days 1, 2, 8, and 9 (2/7 schedule) or days 1 to 5 (5/14 schedule) of a 14-day cycle. Results:. In patients with multiple myeloma or Waldenström macroglobulinemia ( n = 71), the determined MTDs were 300 mg/day (2/7 schedule) and 240 mg/day (5/14 schedule). Median oprozomib treatment durati.
More from Clinical Cancer Research - Recent Issues (abstracts):
PR Newswire 08/12/2019 10:00
Known as limited distribution drugs (LDDs), these specialty medicines treat certain types of multiple sclerosis (MS), Lambert-Eaton myasthenic syndrome (LEMS) and a form of non-Hodgkin's lymphoma (NHL), among other complex conditions.
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PubMed News (NIH) 08/08/2019 21:00
NCI Waldenstrom Macroglobulinemia Genome-wide Association Study. (. |. )
More from PubMed News (NIH): 08/04/2019 02:25
Compared with individuals without cancer, there was a statistically significant association between BRCA2 mutations and risk of non-Hodgkin lymphoma but not Hodgkin lymphoma.
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