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PubMed News (NIH) 10/01/2019
Contributors : Hao Pan ; Yuhong Wang ; Zhangui Tang Series Type : Expression profiling by array Organism : Homo sapiens. Oral squamous cell carcinoma (OSCC) accounts for the high mortality rate and morbidity in head and neck cancer. Data for analysis were obtained from the microarray data of 6 OSCC tissues, tissues adjacent to cancer, and contralateral normal tissues.We used the affy package under the R environment to preprocess and normalize the original gene chip data.
PubMed News (NIH) 09/26/2019
Contributors : Fumika Inazuka ; Taeko Dohi ; Yuki I Kawamura Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We obtained transcriptome profiling (RNA-seq) of human esophageal squamous cell carcinoma cell line KYSE150 stabley transfected clones with pIRES2-EGFP vector or human NCCRP1-expression vector by using next generation sequencing.
PubMed News (NIH) 09/26/2019
Contributors : Teruki Hagiwara ; Taeko Dohi ; Yuki I Kawamura Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We obtained transcriptome profiling (RNA-seq) of human esophageal squamous cell carcinoma cell line KYSE30 cells stabley transfected with pIRES2-EGFP vector or human RHCG-expression vector by using next generation sequencing.
PubMed News (NIH) 09/20/2019
Contributors : Shensi Shen ; Stéphan Vagner ; Caroline Robert Series Type : Expression profiling by array Organism : Homo sapiens. Identify transcriptionnally and translationally regulated mRNA in melanoma parental and persister cells In this dataset, we include expression data of A375 melanoma drug-naïve parental cells and A375 melanoma persister cells that survived from BRAF and MEK inhibition.
PubMed News (NIH) 09/17/2019
Contributors : Takashi Sato ; Hideo Watanabe Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Lineage-specific transcriptional regulators control differentiation states not only during normal development but also during cancer evolution.
PubMed News (NIH) 09/13/2019
Contributors : Mayumi Ito ; Qi Sun Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. We compared the gene signatures of mouse melanocyte stem cells and the melanoma tumor derived from them upon Braf V600E mutation and loss of Pten, as well as the heterogeneity of the melanoma cells by single cell RNAseq.
PubMed News (NIH) 09/10/2019
Contributors : Philipp Jurmeister ; Bockmayr Michael ; David Capper ; Frederik Klauschen Series Type : Methylation profiling by array Organism : Homo sapiens. Head and neck squamous cell carcinoma (HNSC) patients are at risk of suffering from both pulmonary metastases or a second squamous cell carcinoma of the lung (LUSC).
PubMed News (NIH) 09/03/2019
Contributors : Lin Wang ; Zongwu Lin Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Inflammatory signals can promote tumorigenesis. The pro-inflammatory cytokine interleukin (IL)-1β is overexpressed in many types of tumor; however, it is unclear whether it directly interacted with oncogenes in esophageal squamous cell carcinoma. In this study, we performed RNA sequencing to identify tumorgenesis and recurrence-related factors in ESCC and identified FRAS1-related extracellular matrix protein (FREM)2 as a candidate oncogene. IL-1β and IL-1R1 were upregulated in ESCC tissue, which was accompanied by elevated Frem2 expression. FREM2 formed complex with IL-1R1 at the cell surface and promoted ESCC cell p.

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