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PubMed News (NIH) 10/15/2019
Contributors : Corina Lorz ; Sara Lázaro ; Miriam Pérez-Crespo ; Jesús M Paramio ; Mirentxu Santos Series Type : Expression profiling by array Organism : Mus musculus. Here we describe novel murine models of High Grade Neuroendocrine Lung Carcinomas driven by the loss of four tumor suppressors: deletion of Rb, PTEN, and p53, in a Rbl1 null background, in a wide variety of lung epithelial cells produces Large Cell Neuroendocrine Carcinoma whereas inactivation of these genes exclusively in basal cells leads to the development of Small Cell Lung Carcinoma, showing that Keratin K5 expressing cells contribute to the development/act as cell of origin of Small Cell Lung Carcinoma differentially influencing the lung cancer type developed.
PubMed News (NIH) 10/01/2019
Contributors : Keqiang Zhang ; Jinghan Wang ; Lu Yang ; Dan Raz Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. The experiment was designed to display differential gene expression profiling changes in two human non-small cell lung cancer cells A549 and H1299 upon knockout of USP22 gene, by using RNAseq technology.
PubMed News (NIH) 09/26/2019
Contributors : Zhixiang Zuo ; Xingyang Li ; Yongbin Chen Series Type : Expression profiling by high throughput sequencing ; Other Organism : Homo sapiens. In addition to perform the m6A-seq in A549 cells, we sequenced RNA obtained from the immuno-purified complex of YTHDF1 (RIP-seq) to reveal YTHDF1 bound mRNAs, 3,676 genes were shared (m6A-seq+RIP-seq) as high-confident targets of YTHDF1 , which were mapped to cell cycle and tumor (including lung cancer) related signaling pathways in the KEGG pathway database.
PubMed News (NIH) 09/17/2019
Contributors : Takashi Sato ; Hideo Watanabe Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Lineage-specific transcriptional regulators control differentiation states not only during normal development but also during cancer evolution.
PubMed News (NIH) 09/11/2019
Contributors : Hyejin Choi ; Deng Jiehui ; Li Shuai ; Kwok K Wong ; Jedd D Wolchok ; Taha Merghoub Series Type : Expression profiling by array Organism : Mus musculus. KRAS is one of the driver oncogenes in non-small cell lung cancer (NSCLC), but remains refractory to current modalities of targeted pathway inhibition, which include inhibiting downstream kinase MEK to circumvent KRAS activation.
PubMed News (NIH) 09/10/2019
Contributors : Philipp Jurmeister ; Bockmayr Michael ; David Capper ; Frederik Klauschen Series Type : Methylation profiling by array Organism : Homo sapiens. Head and neck squamous cell carcinoma (HNSC) patients are at risk of suffering from both pulmonary metastases or a second squamous cell carcinoma of the lung (LUSC).
PubMed News (NIH) 09/03/2019
Contributors : R Rezzonico ; N Nottet ; B Mari ; P Barbry ; K Lebrigand Series Type : Expression profiling by high throughput sequencing ; Expression profiling by array Organism : Homo sapiens. Lung cancer is the leading cause of cancer death worldwide, with poor prognosis and a high rate of recurrence despite early surgical removal.
PubMed News (NIH) 08/22/2019
Contributors : Bin Shan ; Simon Alsager Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. A549 and MDA-MB-231 cells were transfected with the Bloom-specific siRNA. Total RNA was extracted using Trizol at 48 hours after transfection. RNA-SEQ was carried out to profile the gene expression in both culture conditions.
PubMed News (NIH) 08/06/2019
Contributor : Hyuk-Jin Cha Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Analysis of TGF-β induced mesenchymal type of lung cancer compared with control A549 lung cancer cell at gene expression level. In order to investigate the characteristics of mesenchymal like lung cancer cell, we established mesenchymal type of lung cancer cell (TD) with chronic exposure with TGF-β. After we established TD cell line, RNA-seq was performed with total RNA extracted from TD and parental A549 cells.

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