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ClinicalTrials.gov 02/15/2019 11:27
Conditions : Acute Myeloid Leukemia; Myelodysplastic Syndrome With Excess Blasts-2 Interventions : Drug: AG-120; Drug: Placebo for AG-120; Drug: AG-221; Drug: Placebo for AG-221 Sponsors : Stichting Hemato-Oncologie voor Volwassenen Nederland; Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG) Not yet recruiting.
ClinicalTrials.gov 02/15/2019 11:27
Supportive care including blood product transfusions, antiemetic medications, antiviral and antifungal medications, growth factor support, tumor lysis syndrome prophylaxis, or empiric antibiotics may be used at the clinical discretion of the provider.
ClinicalTrials.gov 02/08/2019 09:17
Conditions : Blasts 5 Percent or More of Bone Marrow Nucleated Cells; Central Nervous System Neoplasm; ETV6 Gene Rearrangement; Infantile Fibrosarcoma; NTRK1 Fusion Positive; NTRK1 Gene Rearrangement; NTRK2 Fusion Positive; NTRK2 Gene Rearrangement; NTRK3 Fusion Positive; NTRK3 Gene Rearrangement; Recurrent Acute Leukemia; Refractory Acute Leukemia; Solid Neoplasm Intervention : Drug: Larotrectinib Sponsors : Children's Oncology Group; National Cancer Institute (NCI) Not yet recruiting.
ClinicalTrials.gov 02/06/2019 10:19
Condition : Chronic Myeloid Leukemia Interventions : Drug: Bosutinib; Drug: Ropeginterferon Sponsors : St. Olavs Hospital; Haukeland University Hospital; Oslo University Hospital; University Hospital of North Norway; Helse Stavanger HF; Henri Mondor University Hospital; Hôpital René Huguenin; Hôpital Mignot, Versailles Paris; Uppsala University Hospital; Odense University Hospital Not yet recruiting.
ClinicalTrials.gov 01/31/2019 10:51
Conditions : Chronic Lymphocytic Leukemia (CLL); Small Lymphocytic Leukemia (SLL) Interventions : Drug: Zanubrutinib; Drug: Obinutuzumab; Drug: Venetoclax Sponsors : Memorial Sloan Kettering Cancer Center; BeiGene USA, Inc.; Roche-Genentech; Massachusetts General Hospital Not yet recruiting.
ClinicalTrials.gov 01/31/2019 10:49
Conditions : Blasts 5 Percent or More of Bone Marrow Nucleated Cells; IDH2 Gene Mutation; Recurrent Acute Myeloid Leukemia Interventions : Drug: Enasidenib Mesylate; Drug: Liposome-encapsulated Daunorubicin-Cytarabine Sponsors : Jonsson Comprehensive Cancer Center; National Cancer Institute (NCI) Not yet recruiting.
ClinicalTrials.gov 01/30/2019 07:39
The current national acute lymphoblastic leukaemia (ALL) trial in adults investigated whether a low (reduced) intensity chemotherapy regimen prior to transplant could improve the outcome of patients with ALL who are over 40 years of age.
ClinicalTrials.gov 01/23/2019 08:47
Conditions : Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Blasts 0.1 Percent or More of Bone Marrow Nucleated Cells; Blasts 5 Percent or More of Bone Marrow Nucleated Cells; Recurrent Acute Myeloid Leukemia; Recurrent High Risk Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia Interventions : Drug: Azacitidine; Drug: Cytarabine; Drug: Fludarabine Phosphate; Drug: Methotrexate; Drug: Pevonedistat; Drug: Therapeutic Hydrocortisone Sponsor : National Cancer Institute (NCI) Not yet recruiting.
ClinicalTrials.gov 01/23/2019 08:45
Conditions : Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute; Renal Insufficiency; Hepatic Impairment Interventions : Drug: Azacitidine; Drug: Pevonedistat Sponsor : Millennium Pharmaceuticals, Inc. Not yet recruiting.

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