Millie: Search Results

Contributors : André F Rendeiro ; Thomas Krausgruber ; Nikolaus Fortelny ; Fangwen Zhao ; Thomas Penz ; Matthias Farlik ; Linda C Schuster ; Amelie Kuchler ; Szabolcs Tasnády ; Marienn Réti ; Mátrai Zoltán ; Donat Alpar ; Csaba Bödör ; Christian Schmidl ; Christoph Bock Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease.

Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing Organism : Homo sapiens. Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease.

Contributors : Daniel Sasca ; Anna Dolnik ; Lars Bullinger ; Thomas Kindler Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Neural cell adhesion molecule 1 (NCAM1; also known as CD56) is expressed in up to 20% of acute myeloid leukemia (AML) patients.

Contributors : John Cowell ; Tianxiang Hu Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Purpose: Oncogenic transformation of hematopoietic stem cells by chimeric fusion kinases causing constitutive activation of FGFR1 leads to a stem cell leukemia/lymphoma (SCLL) syndrome, accompanied by widespread dysregulation of gene activity.

Microarray analysis was performed to determine the changes in global gene expression profiles during apoptosis of a T cell leukemia induced by the histone deacetylase inhibitor, Trichostatin A. Drug treatment induced the upregulation and repression of a number of genes.

Contributors : Fanny L Casado ; Borhane Guezguez ; Jamie D McNicol ; Aline Fiebig-Comyn ; Zoya Shapovalova ; Kyle Salci ; Tony J Collins ; Mickie Bhatia Series Type : Expression profiling by array Organism : Homo sapiens. Hematopoietic progenitors from AML patients express the aryl hydrocarbon receptor signaling pathway.

Status Public on Jan 30, 2019 Title Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Contributors : Luisa Schmidt ; Thomas Eder ; Florian Grebien Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. The gene encoding the transcription factor C/EBPα is mutated in 10-15% of all patients with de novo acute myeloid leukemia (AML).

These findings connect maturation and aging of the hematopoietic system to leukemia age specificity.

Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. This SuperSeries is composed of the SubSeries listed below.

Contributors : Meena Kanduri ; Chandrasekhar Kanduri Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencing Organism : Homo sapiens. We studied global distribution of hydroxymethylation (5hmC) and DNA methylation (5mC) in during normal B-cell development and CLL maturation.

Contributor : Amitava Sengupta Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. We have used chromatin immunoprecipitation followed by high throughput sequencing to map regions of chromatin remodeler binding in Control and KDM6A knock down AML cells.

Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by array Organism : Homo sapiens. This SuperSeries is composed of the SubSeries listed below.

Contributors : Helai P Mohammad ; Kimberly N Smitheman ; Tesa M Severson ; Satyajit R Rajapurkar ; Michael T McCabe ; Natalie Karpinich ; James Foley ; Melissa B Pappalardi ; Ashley Hughes ; Wendy Halsey ; Elizabeth Thomas ; Christopher Traini ; Kelly E Federowicz ; Jenny Laraio ; Fredrick Mobegi ; Geraldine Ferron-Brady ; Rabinder K Prinjha ; Christopher L Carpenter ; Ryan G Kruger ; Lodewyk Wessels Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Combined treatment with all-trans retinoic acid and GSK2879552 results in synergistic effects on gene expression, cell proliferation, markers of differentiation, and, most importantly, cytotoxicity.

Multiple oncogenic mutations in acute myeloid leukemia utilize proton partitioning to enhance growth by epigenetically upregulating H+/lactate-co-transporter, MCT4, shuttling protons extracellularly to increase intracellular pH.

Following engraftment into immunodeficient mice, transduced HSPCs give rise to human myeloid leukemia whereas untransduced HSPCs give rise to human immune cells in the same mice.

Analysis provides insight into function of KLF4 in leukemia.

Contributors : Van T Hoang ; Gabriela Salinas ; Birgitta E Michels ; Martin Zörnig ; Daniela S Krause Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. We examine the oncogenic function of the Far Upstream Element Binding Protein 1 (FUBP1) in leukemia-initiating cells.

Contributor : Lars Bullinger Series Type : Expression profiling by array Organism : Homo sapiens. Many cases of acute myeloid leukemia (AML) are associated with mutational activation of RTKs such as FLT3. However, RTK inhibitors have limited clinical efficacy as single agents, indicating that AML is driven by concomitant activation of different signaling molecules. We used a functional genomic approach to identify RET, encoding an RTK not previously implicated in AML, as essential gene in different AML subtypes, and observed that RET-dependent AML cells show activation of RET signaling via ARTN/GFRA3 and NRTN/GFRA2 ligand/co-receptor complexes.

In a mouse model of human t(8;21) leukemia, E2-2 suppression accelerates leukemogenesis.

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