Search Results
36 results
Your search is now limited to «Leukemia» expert search.
Your search is now limited to only one Source. To return to results from all sources click here.
PubMed News (NIH) 04/12/2019
Contributors : Robert Burns ; Luke Christiansen ; Jesus Izaguirre-Carbonell Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. We performed genome-wide profiling of H3K9me3, H3K9me1, H3K27me3, and H3K36me3 by ChIP-seq in JMJD1C knockout or mutated MLL-AF9 leukemia cells.
PubMed News (NIH) 04/10/2019
Contributors : Kim R Kampen ; Laura Fancello ; Tiziana Girardi ; Fabricio Loayza ; Benno Verbelen ; Stijn Vereecke ; Gianmarco Rinaldi ; Jelle Verbeeck ; Joyce O de Beeck ; Karin Thevissen ; Bruno Cammue ; Pieter Vermeersch ; David Cassiman ; Jan Cools ; Sarah-Maria Fendt ; Reuven Agami ; Mark Fiers ; Kim De Keersmaecker Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Somatic ribosomal protein defects have recently been described in cancer, yet their impact on cellular transcription and translation remain poorly understood.
PubMed News (NIH) 04/04/2019
Contributors : Ramin Radpour ; Adrian F Ochsenbein Series Type : Expression profiling by array Organism : Homo sapiens. We performed a comprehensive transcriptomic profiling of BM derived leukemia stem cells (LSCs) and leukemia progenitor cells (LPCs) together with paired CD8+ T cells of AML patients from different molecular risk groups.
PubMed News (NIH) 03/26/2019
Contributors : Biniam Adane ; Craig T Jordan Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. To investigate the function of NOX2 (CYBB) in leukemia stem cells, we created leukemia by tranforming primitive hematopoetic cells isolated from wild type and NOX2-KO mice with NUP98/HOXA9 and BCR/ABL oncogenes, isolated mRNA, and performed RNA-seq experiments to profile transcriptional changes upon NOX2 loss.
PubMed News (NIH) 03/16/2019
Contributors : Corina Schneidawind ; Kathy-Ann Secker Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Previous studies have identified frequent MLL-AF4 chromosomal translocation breakpoints in patients. Using CRISPRscan, we designed different sgRNAs recognizing patient-specific sequences in intron 11 of the MLL and exon 3 of the AF4 genes, respectively. Using plasmid- and virus-free delivery of sgRNAs with Cas9 protein, we nucleofected CD34+ target cells derived from human umbilical cord blood. Following nucleofection, the cells were maintained in liquid culture supplemented with cytokines and chemokines optimized for growth of MLLr cells. On day 30 (MLL-AF4) of liquid culture, MLL translocations wer.
PubMed News (NIH) 03/13/2019
Status Public on Mar 13, 2019 Title Dependence on Myb expression is attenuated in myeloid leukemia with N-terminal CEBPA mutations Organism Mus musculus Experiment type Expression profiling by high throughput sequencing Summary Mutations altering the normal function of C/EBPα are frequent in acute myeloid leukaemia with normal karyotype.
PubMed News (NIH) 03/12/2019
Contributors : Adam Mead ; Benjamin Povinelli Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We report on the characterization of JMML hematopoietic stem and progenitor cells (HSPCs). In order to molecularly characterize these populations we preformed bulk RNA-seq on purified cord blood and JMML HSCs, GMPs, and JMML double positives (+/+). We identified a conserved molecular hierarchy in JMML with high stem cell gene expression in HSCs, high progenitor and cell cycle gene expression in GMPs. We identified enriched gene sets in JMML HSCs vs CB HSCs, and find a number of potential therapeutic targets expressed in JMML.

Therapeutic Areas

Clinical Trials and Phases

Business Issues

Companies - Public

Companies - Venture Funded

Financial Results

Global Markets

Global Risk Factors

Government Agencies

Job Titles

Legal and Regulatory

Cell Receptors

Cells

Diagnostics and Therapeutics

Diseases

Drugs - Brand Names

Drugs - Generic

Enzymes

Genes

Health Care

Health and Wellness

Human Anatomy

Mechanisms of Action

Medical Devices

Proteins

Sources

Strategic Scenarios

Trends

Hints:

On this page, you see the results of the search you have run.  You may also view the following:

  •  Click on this drop-down menu on the right hand side of the page, to choose between the machine learning-produced Insights Reports, or the listing of concepts extracted from the results, in chart or list format. 


  •  View the number of search results returned for the search in each of your collections, and click on any of those numbers to view the entire listing of results from the chosen collection.

  •  Use the search adjustment drop-downs to change the scope, sorting, and presentation of your results.

  •  Show or hide the record’s caption (content description).

  •  Show actions that can be made with the search result record.

  •  Click on the Save button after running your search, to save it so that its results will be updated each time relevant new content is added to the designated collection. You may choose to be notified via search alerts.

Click here for more info on Search Results

Click here for more info on Machine Learning applications