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PubMed News (NIH) 02/21/2019 23:00
Contributors : André F Rendeiro ; Thomas Krausgruber ; Nikolaus Fortelny ; Fangwen Zhao ; Thomas Penz ; Matthias Farlik ; Linda C Schuster ; Amelie Kuchler ; Szabolcs Tasnády ; Marienn Réti ; Mátrai Zoltán ; Donat Alpar ; Csaba Bödör ; Christian Schmidl ; Christoph Bock Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease.
PubMed News (NIH) 02/11/2019 23:00
Contributors : John Cowell ; Tianxiang Hu Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. Purpose: Oncogenic transformation of hematopoietic stem cells by chimeric fusion kinases causing constitutive activation of FGFR1 leads to a stem cell leukemia/lymphoma (SCLL) syndrome, accompanied by widespread dysregulation of gene activity.
PubMed News (NIH) 01/31/2019 23:00
Contributors : Fanny L Casado ; Borhane Guezguez ; Jamie D McNicol ; Aline Fiebig-Comyn ; Zoya Shapovalova ; Kyle Salci ; Tony J Collins ; Mickie Bhatia Series Type : Expression profiling by array Organism : Homo sapiens. Hematopoietic progenitors from AML patients express the aryl hydrocarbon receptor signaling pathway.
PubMed News (NIH) 01/28/2019 23:00
Contributors : Luisa Schmidt ; Thomas Eder ; Florian Grebien Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus. The gene encoding the transcription factor C/EBPα is mutated in 10-15% of all patients with de novo acute myeloid leukemia (AML).
PubMed News (NIH) 01/22/2019 23:00
Contributors : Meena Kanduri ; Chandrasekhar Kanduri Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Methylation profiling by high throughput sequencing Organism : Homo sapiens. We studied global distribution of hydroxymethylation (5hmC) and DNA methylation (5mC) in during normal B-cell development and CLL maturation.
PubMed News (NIH) 01/15/2019 23:00
Contributors : Helai P Mohammad ; Kimberly N Smitheman ; Tesa M Severson ; Satyajit R Rajapurkar ; Michael T McCabe ; Natalie Karpinich ; James Foley ; Melissa B Pappalardi ; Ashley Hughes ; Wendy Halsey ; Elizabeth Thomas ; Christopher Traini ; Kelly E Federowicz ; Jenny Laraio ; Fredrick Mobegi ; Geraldine Ferron-Brady ; Rabinder K Prinjha ; Christopher L Carpenter ; Ryan G Kruger ; Lodewyk Wessels Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Combined treatment with all-trans retinoic acid and GSK2879552 results in synergistic effects on gene expression, cell proliferation, markers of differentiation, and, most importantly, cytotoxicity.
PubMed News (NIH) 12/22/2018 23:00
Contributors : Van T Hoang ; Gabriela Salinas ; Birgitta E Michels ; Martin Zörnig ; Daniela S Krause Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. We examine the oncogenic function of the Far Upstream Element Binding Protein 1 (FUBP1) in leukemia-initiating cells.
PubMed News (NIH) 12/20/2018 23:00
Contributor : Lars Bullinger Series Type : Expression profiling by array Organism : Homo sapiens. Many cases of acute myeloid leukemia (AML) are associated with mutational activation of RTKs such as FLT3. However, RTK inhibitors have limited clinical efficacy as single agents, indicating that AML is driven by concomitant activation of different signaling molecules. We used a functional genomic approach to identify RET, encoding an RTK not previously implicated in AML, as essential gene in different AML subtypes, and observed that RET-dependent AML cells show activation of RET signaling via ARTN/GFRA3 and NRTN/GFRA2 ligand/co-receptor complexes.

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