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PubMed News (NIH) 09/18/2019
Contributors : Anna J Peired ; Roberto Semeraro ; Paola Romagnani Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Purpose: Using single-cell RNA sequencing (scRNAseq), Young et al. (Science, 2018, PMID 30093597) recently identified a canonical cancer transcriptome as the possible cell of origin of papillary renal cell carcinoma (pRCC) that matched a rare proximal convoluted tubular cell population characterized as VCAM1+ SLC17A3+ SLC7A13-, a cell cluster signature defined as PT1. The goal of this study is to compare pRCC transcriptome to human renal progenitor cell (RPC) transcriptome. Methods: To compare the pRCC cells with PT1 features to our RPC population, we analyzed Young pRCC scRNAseq data set.
PubMed News (NIH) 07/31/2019
Contributors : Libin Yan ; Haoran Liu Series Type : Non-coding RNA profiling by array Organism : Homo sapiens. Finding the downstream miRNAs of SETD2 in the renal cell carcinoma cell line the coordinated expression of SETD2-miRNAs-MAPK/JNK may be predictive of poor prognostic in patients with RCC.

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