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ClinicalTrials.gov 10/17/2019 08:27
Condition : Acute Kidney Injury Intervention : Sponsor : Uppsala University Completed.
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Human medicines European public assessment report (EPAR): Retacrit, epoetin zeta, Anemia,Blood Transfusion, Autologous,Kidney Failure, Chronic,Cancer, Date of authorisation: 18/12/2007, Revision: 24, Status: Authorised.
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Purpose:. Programmed death-ligand 1 (PD-L1) status by IHC is prognostic in metastatic renal cell carcinoma (mRCC), and its role as a potential predictive biomarker is under investigation. Using tumor tissue from the METEOR (NCT01865747) and CABOSUN (NCT01835158) clinical trials, we explored whether PD-L1 expression and the extent of the immune cell infiltrate can serve as prognostic and/or predictive biomarkers for cabozantinib and other targeted agents. Experimental Design:. IHC double staining for PD-L1 and CD45/CD163 (immune cell markers) was performed on tumor tissue from METEOR ( n = 306) and CABOSUN ( n = 110) clinical trials. Immune cell density and MET expression levels were also analyzed. Our primary aim was to correlate progression-
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Lower EVL could assist in better long-term postoperative renal function preservation.
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Top Class Actions 10/03/2019 07:00
Along with the increased risk between usage of a PPI and kidney disease, other connections were found with upper gastrointestinal cancer, chronic kidney disease, and fatal cases of cardiovascular disease.
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Annals of Oncology 09/30/2019 20:00
Abstract. Background. Renal transplantation is known to be associated with increased risk of malignancy. Concurrent presence of malignant diseases and transplantation may influence overall survival. This study summarizes our 35-year experience in breast cancer (BC) in renal transplant patients focusing on the incidence of BC and its impact on survival of this population. Methods. Prospectively collected data of female patients treated with renal transplantation for chronic renal failure from 1973 to 2017 were analysed. Patients diagnosed with BC were identified. Age at transplantation, age at BC diagnosis, date and causes of death were recorded for all patients. BC incidence and overall survival were calculated. Kaplan-Meier and Cox proportion.
Business Wire 09/30/2019 02:45
... WHIM syndrome, a rare, inherited, primary immunodeficiency disease, and is currently also under investigation in combination with axitinib in the Phase 2a portion of an open-label Phase 1/2 clinical trial in clear cell renal cell carcinoma (ccRCC.
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PubMed News (NIH) 09/30/2019
Overall design Examination of 19 RNA samples of clear cell renal cell carcinoma Raw data has not been provided to protect the privacy of the human subjects.
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GlobeNewswire 09/28/2019 02:30
Outcomes for late-line metastatic renal cell carcinoma are often poor using currently available medications with similar mechanism of action,” said Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center, who will present the data.
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