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PubMed News (NIH) 10/09/2019
Contributors : Qing Zhang ; Giada Zurlo ; Travis Ptacek ; Jeremy Simon Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Protein hydroxylation extensively regulates cellular signaling by affecting protein stability, activity, and interactome, therefore contributing to the pathogenesis of various diseases including cancers.
PubMed News (NIH) 10/05/2019
Contributors : Natalia Vydra ; Wieslawa Widlak ; Tomasz Stokowy Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. Heat Shock Transcription Factor 1 (HSF1) is a well-known regulator of gene expression during acute environmental stress that enables the cells to survive.
PubMed News (NIH) 10/03/2019
Contributors : Massimiliano Mazzone ; Paweł Bieniasz-Krzywiec ; Rosa Martín-Pérez ; Manuel Ehling ; Melissa García-Caballero ; Sotiria Pinioti ; Samantha Pretto ; Roel Kroes ; Chiara Aldeni ; Mario Di Matteo ; Hans Prenen ; María V Tribulatti ; Ann Smeets ; Agnes Noel ; Oscar Campetella ; Giuseppe Floris ; Jo A Van Ginderachter Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. RNAseq was performed on PoEMs (CD11b+, F4/80+, PDPN+) vs. non-PoEMs (CD11b+, F4/80+, PDPN-) sorted from orthotopically inoculated 4T1 tumors in WT mice.
PubMed News (NIH) 10/01/2019
Contributors : Yosuke Matsushita ; Masato Komatsu ; Kazuma Kiyotani ; Tetsuro Yoshimaru ; Toyomasa Katagiri Series Type : Expression profiling by array Organism : Homo sapiens. Triple negative breast cancers (TNBC), defined by lacking the expression of oestrogen receptor-alpha (ERa), progesterone receptor, and HER2, is considered to be one of the most aggressive subtypes of all breast cancers.
PubMed News (NIH) 09/25/2019
Although clinical applications of selective estrogen receptor modulators (SERMs), which directly interact with ERα to alter ERα activity, have been effective as a first line of treatment for breast cancer patients, a large subset of the patients will develop resistance after prolonged use of SERMs.
PubMed News (NIH) 09/24/2019
Contributors : Richly Holger ; Kaymak Aysegul Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. RNAseq analysis upon KD of ZRF1 to prove that depletion of ZRF1 results in the acquisition of metastatic behavior and drug resistance via misregulation of cell death and cell survival related pathways in MCF7 cells.
PubMed News (NIH) 09/24/2019
Contributors : Yuichi Mitobe ; Kazuhiro Ikeda ; Kuniko Horie-Inoue ; Satoshi Inoue Series Type : Expression profiling by array Organism : Homo sapiens. To examine the role of long non-coding RNA TMPO-AS1 in breast cancer, MCF-7 cells were treated with siRNAs targeting TMPO-AS1 (siTMPO-AS1) or control siRNA (siControl).
PubMed News (NIH) 09/18/2019
Contributors : Ewa E Hennig ; Magdalena Piątkowska ; Krzysztof Goryca ; Ewelina Pośpiech ; Agnieszka Paziewska ; Jakub Karczmarski ; Anna Kluska ; Elżbieta Brewczyńska ; Jerzy Ostrowski Series Type : Genome variation profiling by SNP array Organism : Homo sapiens. Background: Current reports suggest that a certain minimum plasma concentration of (Z)-endoxifen is required for breast cancer patient to benefit from tamoxifen therapy.
PubMed News (NIH) 09/15/2019
Contributors : Martin DUTERTRE ; Iris TANAKA ; Alina CHAKRABORTY ; Olivier SAULNIER ; Clara BENOIT-PILVEN ; Sophie VACHER ; Eric W LAM ; Ivan BIECHE ; Olivier DELATTRE ; Didier AUBOEUF ; Stéphan VAGNER Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. We explored the regulation of alternative splicing in a cell model of breast cancer resistance to doxorubicin, and the impact of the depletion of two splicing factors (ZRANB2 and SYF2) in this context.
PubMed News (NIH) 09/13/2019
Contributors : P Sharma ; W E Barlow ; A K Godwin ; E E Parkes ; L A Knight ; S M Walker ; R D Kennedy ; D P Harkin ; G E Logan ; C J Steele ; S M Lambe ; S Badve ; Y Gokmen-Polar ; H B Pathak ; K Isakova ; H M Linden ; P Porter ; L Pusztai ; A M Thompson ; D Tripathy ; G N Hortobagyi ; D F Hayes Series Type : Expression profiling by array Organism : Homo sapiens. Purpose: The purpose of this study was to independently validate two biomarkers, a 44-gene DNA Damage Immune Response (DDIR) signature and stromal tumor-infiltrating lymphocytes (sTILs), as prognostic markers in TNBC patients treated with adjuvant doxorubicin (A) and cyclophosphamide © in SWOG 9313.
PubMed News (NIH) 09/12/2019
Status Public on Sep 12, 2019 Title Immune effector monocyte - neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer Organism Mus musculus Experiment type Expression profiling by high throughput sequencing Summary Metastatic behaviour varies significantly among breast cancers.

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