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Biochemists from RUDN University (Russia) and the University of Bari (Italy) report a group of compounds that can become a molecular scaffold for new drugs for Alzheimer's disease. They have demonstrated that derivatives of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole, or HHAI, are effective inhibitors of acetylcholinesterase and butyrylcholinesterase—enzymes whose increased activity can worsen the condition in this disease. The article is published in the European Journal of Medicinal Chemistry.
Cognitive impairment with the potential for early onset dementia in 911 World Trade Center responders is continuing to be investigated by researchers monitoring the health of thousands of responders. A new study led by Stony Brook University that includes 1,800 responders reveals that post-traumatic stress disorder (PTSD) is strongly associated with onset of mild cognitive impairment (MCI). The study, published early online in Alzheimer's & Dementia: Diagnosis, Assessment, and Disease Monitoring, also found that longer duration exposures working at Ground Zero results in an increased risk of cognitive impairment in individuals who carry a specific gene associated with dementia.
A team of scientists from the Moscow Institute of Physics and Technology (MIPT) and Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS) studied one hereditary genetic mutation to discover general molecular mechanisms that may lead both to early onset of Alzheimer's disease and to the form of the disease caused by age-related changes in human body.
A gene that can become mutated and cause a rare balance disorder also regulates the behavior of an enzyme that increases the risk for Alzheimer's disease (AD), according to a new study by researchers at Massachusetts General Hospital (MGH) to be published in the journal Cell on August 22, 2019.
Protein aggregation—in which misfolded proteins clump together to form large fibrils—has been implicated in many diseases including Alzheimer's, Parkinson's, and type II diabetes. While the exact role these fibrils play in diseases isn't fully understood, many of the current treatments for diseases like Alzheimer's and Parkinson's target the aggregation process. However, finding the right treatment protocols for these drugs, which can be toxic in large doses, is challenging.

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