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American Diabetes Journals 10/21/2019 15:00
The SEARCH for Diabetes in Youth (SEARCH) study found cardiac autonomic dysfunction in 17% of their cohort of young adults with youth-onset T2D (compared with a lean control group), a higher prevalence than that seen in young adults with type 1 diabetes (17% vs. 12%) (17 ...
American Diabetes Journals 10/21/2019 15:00
OBJECTIVE. Fixed-ratio combinations of basal insulin plus glucagon-like peptide 1 receptor agonist (GLP-1 RA) allow concomitant administration of two proven complementary injectable therapies for type 2 diabetes. This study investigated switching to a titratable fixed-ratio combination of insulin glargine plus lixisenatide (iGlarLixi) in patients with type 2 diabetes receiving daily or weekly GLP-1 RA therapy. RESEARCH DESIGN AND METHODS. LixiLan-G, a randomized, open-label, 26-week trial, compared switching to iGlarLixi versus continuing prior GLP-1 RA in patients with type 2 diabetes and HbA 1c 7–9% (53–75 mmol/mol) taking maximum tolerated doses of a GLP-1 RA daily (60% on liraglutide once daily or exenatide twice daily) or weekly (40% on

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