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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies worldwide, associated with poor prognosis even when diagnosed at an early clinical stage (CS). Despite advances in surgery, radiotherapy, and chemotherapy, the 5-year overall survival rate is only 7.0-8.5% [1]. FOLFIRINOX (5-fluorouracil, irinotecan, and oxaliplatin) and nab-paclitaxel plus gemcitabine are first-line treatment options in the metastatic setting, with a median overall survival of less than 1 year [2,3].
PubMed News (NIH) 09/18/2019
Contributors : Ewa E Hennig ; Magdalena Piątkowska ; Krzysztof Goryca ; Ewelina Pośpiech ; Agnieszka Paziewska ; Jakub Karczmarski ; Anna Kluska ; Elżbieta Brewczyńska ; Jerzy Ostrowski Series Type : Genome variation profiling by SNP array Organism : Homo sapiens. Background: Current reports suggest that a certain minimum plasma concentration of (Z)-endoxifen is required for breast cancer patient to benefit from tamoxifen therapy.

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