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PubMed News (NIH) 06/04/2020
Contributors : Matthew E Burow ; Kenneth Nephew ; Fang Fang ; Douglas R Busch ; Aaron Buechlein Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Depletion of ERK5 expression using the CRISPR/Cas9 system in MDA-MB-231 and Hs-578T cells resulted in loss of mesenchymal features, as observed through gene expression profile and cell morphology, and suppressed TNBC cell migration.
PubMed News (NIH) 06/04/2020
Contributors : Alexander S Roesler ; Elizabeth Lenkiewicz ; Smriti Malasi ; Lacey E Dobrolecki ; Michael T Lewis ; Karen S Anderson ; Michael T Barrett Series Type : Genome variation profiling by genome tiling array Organism : Homo sapiens. We applied DNA content flow cytometry to ten patient derived triple negative breast cancer (TNBC) xenografts (PDXs) from the Baylor College of Medicine (BCM).
Background and importance. Neoadjuvant chemotherapy has become the standard treatment for patients with inoperable locally advanced tumours, and it is also optional for operable stages. The literature reports rates of 20–30% and 56–66% for pathological complete response (pCR) in patients treated with combinations of anthracyclines and taxanes, and dual blockade of human epidermal growth factor receptor 2 (HER2), respectively. Aim and objectives. To assess the effectiveness of neoadjuvant chemotherapy in stage II/III breast cancer according to expression of HER2 and hormonal receptors (HR) based on pCR. Material and methods. A retrospective observational study was carried out between January 2016 and December 2018 in a second level hospital. Th.
In the HER2CLIMB study, patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer with brain metastases (BMs) showed statistically significant improvement in progression-free survival (PFS) with tucatinib.

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