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Fight Aging! 08/04/2020 15:48
Today's open access paper outlines an investigation into how the aging of hematopoietic stem cell populations in bone marrow, responsible for producing blood and immune cells, can contribute to age-related dysfunction in the brain. The authors find that detrimental effects are mediated by circulating levels of CyPA, a signaling factor that is a part of the senescence-associated secretory phenotype (SASP), an inflammatory mix of signal molecules produced by senescent cells. The focus here is on direct inhibition of CyPA as an approach to therapy, but senolytic treatments to clear senescent cells may be the more useful approach if these errant cells are indeed the source of raised levels of CyPA. This seems reasonable, but is yet to be proven.
Fight Aging! 08/04/2020 06:22
As a general rule, people care too much about their hair and too little about their blood vessels. One can live without hair. It is interesting to see both (a) just how much work goes into the regeneration of lost hair, and (b) just how little is known of the fine details by which the capacity to grow hair fades with age. It is this lack of knowledge that leads to the present state of uncertain and largely ineffective interventions for hair growth. No-one is entirely sure as to where the root of the problem lies, or where the most effective points of intervention might be. A great deal of exploration takes place, but success is all too much a matter of luck rather than […]
Fight Aging! 08/04/2020 06:12
Presently available methods of determining whether or not amyloid-β aggregates exist in the brain are expensive and invasive. Amyloid-β forms solid deposits in and around cells in the brain for decades prior to the first obvious signs of neurodegeneration, and people with raised levels of these protein aggregates are more likely to progress to dementia. Early, accurate, low-cost measurements of amyloid-β prior to symptoms could lead to the identification of lifestyle choices that minimize risk, as well as to the development of preventative therapies. Absent assays that can achieve this goal, there is little pressure to develop such treatments, however. Thus it is always good news to see progress towards cost-effective ways to measure amyloi.
Fight Aging! 08/03/2020 16:07
The practice of calorie restriction, eating up to 40% fewer calories while still maintaining an optimal intake of micronutrients, is well demonstrated to slow aging and extend healthy life span in near all species and lineages tested to date. It produces sweeping effects on the operation of metabolism - near everything changes, which has made it something of a challenge to identify the principal points of action. Nonetheless, more efficient operation of the cellular housekeeping mechanisms of autophagy is the most plausible mechanism to account for the majority of the benefits. That calorie restriction fails to extend life when autophagy is disabled is the most telling evidence. The open access paper that I'll point out today is illustrativ.
Fight Aging! 08/03/2020 06:22
Trees can adopt a range of strategies not available to animals in order to live for very long periods of time, but they are not immune to mechanisms of aging. That said, those mechanisms are only broadly similar to the biochemistry of aging in animals. It isn't clear that there is anything useful to learn from long-lived plants insofar as human medicine is concerned. Nonetheless, it is an interesting area of study. The oldest trees on Earth have stood for nearly five millennia, and researchers have long wondered to what extent these ancient organisms undergo senescence, physically deteriorating as they age. A recent paper studying ginkgoes, one of the world's longest-lived trees, even found that they may be able to "escape senescence at the.
Fight Aging! 08/03/2020 06:11
Researchers here note a correlation between receiving influenza vaccination, even once, and the later risk of Alzheimer's disease. This is interesting in the context of the present debate over the mechanisms of Alzheimer's, particularly regarding whether or not persistent viral infection is an important driver of the condition. Inflammation and immune system dysfunction are also clearly important in the progression of neurodegenerative conditions. How exactly influenza vaccines might influence this complex decline is an open question. One might hypothesize that this is mediated by something other than biology - that people more likely to take care of their overall health, and thus have a lesser degree of chronic inflammation and lesser inci.
Fight Aging! 08/02/2020 08:56
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents A Genomic Search for Longevity-Associated Genes Points to Iron Metabolism in Human Agi.
Fight Aging! 07/31/2020 14:59
There are two activities in medical science in which both the academic research community and clinical development industry are truly terrible at achieving results, or indeed even at getting started at all. The first is transfer of programs from academia to industry. The renowned valley of death in the development of new medical biotechnologies is very real; so very many programs languish undeveloped simply because neither side can effectively coordinate with the other. The second is the testing of synergies between multiple therapies that are applied at the same time to the same patient for the treatment of the same condition. We live in a world in which age-related conditions are the result of multiple distinct contributing mechanisms, so.
Fight Aging! 07/31/2020 06:11
Fitness produced by training is here shown to correlate with reduced inflammatory signaling, but has no effect on the burden of senescent cells in old muscle tissue. This is interesting, as the accumulation of senescent cells with age is responsible for a sizable fraction of inflammatory signaling in tissues. Senescent cells secrete a potent mix of signals that cause chronic inflammation and tissue dysfunction, and are an important contributing cause of aging. The likely explanation here is that the cellular adaptations to exercise act to reduce harmful aspects of persistent senescent cell signaling. There is a good deal of research to show that senescent cell signaling can be muted to various degrees. This is probably not as a good a strat.
Fight Aging! 07/30/2020 15:45
Investigation of the comparative biology of aging is one of many notable communities within the broader research community focused on aging and age-related disease. Scientists use comparisons between different species with very different life spans as a way to try to pin down the mechanisms that are most important in aging. Thus there is work on naked mole-rats versus mice, both similarly sized rodents. Whales capable of living for centuries are compared to smaller mammals that are not. Humans are compared to our nearest primate relatives, all of whom are less long-lived than we are. And so forth. One of the more interesting comparisons to be made is between bats and other mammals. It is quite clear that flight requires considerable metabol.
Fight Aging! 07/30/2020 06:22
Researchers here provide evidence to indicate that increased expression of CD47 in aged blood vessels impairs a range of functions, from maintenance of these tissues to the generation of new blood vessels. The latter point is interesting given that capillary networks become less dense with age. This is thought to impair blood flow to tissues and thus contribute to age-related loss of function. The animal evidence here suggests that inhibition of CD47 may be a viable strategy to reduce the impact of aging on the vasculature, and thus also many of the consequences of vascular aging throughout the body. The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, agi.
Fight Aging! 07/30/2020 06:11
We humans have not evolved for optimal function given a continually high calorie intake. We, and all other species, evolved in an environment characterized by periods of feast and famine: we desire food constantly, but nonetheless need some amount of hunger in order to be healthy. Periods of low calorie intake spur increased activity of tissue maintenance mechanisms throughout the body. A lower overall calorie intake minimizes excess visceral fat tissue that causes chronic inflammation and metabolic disease. In this modern society of comfort and cheap calories, all too many people are eating themselves into shorter, less healthy lives. This will continue until the advent of rejuvenation therapies that can meaningfully target the causes of a.
Fight Aging! 07/29/2020 06:22
The raised blood pressure of hypertension can be minimized with age by staying thin and active, type 2 diabetes is near entirely avoidable via much the same strategy, and smoking is just a bad idea. There is a mountain of evidence in each case for these outcomes to negatively impact health and lead to an earlier death. The work here is a reminder that if you want your mind to corrode somewhat more rapidly than would otherwise be the case, there exists a range of bad lifestyle choices that can achieve that goal. A recent study involved 2,675 people with an average age of 50 who did not have dementia. Researchers measured their cardiovascular risk factors at the start of the study: 43% were considered […]
Fight Aging! 07/29/2020 06:11
This open access paper expands on earlier work on cellular senescence in long-lived naked mole-rats. Individuals of this species can live as much as nine times longer than equivalently sized rodents, and are near immune to cancer. In other mammals, senescent cells accumulate with age and disrupt tissue function via their inflammatory signaling. Evidence suggests that this is an important cause of degenerative aging, given that selective destruction of these errant cells produces rejuvenation and extended life span in mice. In naked mole-rats, senescent cells exhibit very little of the harmful signaling that occurs in other mammals. These cells also also self-destruct more readily when stressed. That naked mole-rat senescent cells are more p.
Fight Aging! 07/28/2020 16:22
Today's research materials report on recently presented preliminary evidence, based on work in tissue slices from mouse brains, for oxytocin to dampen the harms done to the function of neurons by amyloid-β. Amyloid-β is one of the few proteins in the body capable of becoming altered in ways that encourage other molecules of amyloid-β to alter in the same way, aggregating into solid deposits in and around cells. This is disruptive to cell function when it occurs in the brain, and rising amyloid-β aggregation is widely thought to be the early, formative stage of Alzheimer's disease. Oxytocin is one of the factors that diminishes with age in blood, identified as potentially interesting in parabiosis studies of recent years. This work was large.
Fight Aging! 07/28/2020 06:11
Researchers here analyze amounts and types of glycans in stem cells isolated from the skin of old and young mice. The differences observed might serve as a biomarker of aging, but also may be a contributing proximate cause of the age-related decline in skin stem cell function. As is usually the case, connecting downstream changes of this nature to the deeper causes of aging is a project yet to make any meaningful progress. It is also unclear as to whether glycan profile changes are a sizable cause of dysfunction versus all of the other possible proximate causes of stem cell functional decline. Aging in the epidermis is marked by a gradual decline in barrier function, impaired wound healing, hair loss, and an increased risk of […]
Fight Aging! 07/27/2020 16:22
As a general rule, one should be skeptical about any and all single studies that identify longevity-associated genes from human data. Typically the results cannot be replicated in different study populations, and the effect sizes are in any case small. Identified gene variants confer only small changes in the odds of reaching a given age. Only a handful of gene variants show up reliably in multiple studies carried out in different human populations. So, unfortunately, however interesting or novel the data in a new study, such as the association of longevity with maintenance of normal iron levels noted in today's open access research paper, there is a good chance that it will remain unconfirmed. Other approaches to determining the genetic co.
Fight Aging! 07/27/2020 06:22
The intestinal lining is an important tissue. Among its other functions, it protects the body from inflammation that can be generated by the actions of gut microbes. This barrier declines with age, and this is thought to be influential in the increased chronic inflammation observed in older people. Ways to spur greater maintenance and repair on the part of cell populations making up intestinal tissue would likely be of great benefit, given the importance of chronic inflammation as a driver of age-related disease. A strong cellular lining is essential for a healthy gut as it provides a barrier to the billions of microbes and harmful toxins present in our intestinal tract. This barrier is often damaged by infection and inflammation, which cau.

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