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PubMed News (NIH) 09/16/2019
Contributors : Christoph Gericke ; Anna Mallone ; Britta Engelhardt ; Roger M Nitsch ; Maria T Ferretti Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. The goal of this study is to investigate the involvement of inflammation in Alzheimer’s disease (AD) and to clarify the signaling pathways involved in the presence of beta-amyloidosis, a hallmark of AD pathogenesis, to help identifying potential targets for therapy.
Benzinga 09/11/2019 07:30
Presenting New Clinical Data from Phase 2 Study in Type 1 Diabetes with Liver Selective GKA Program. Pre-Clinical Data in NASH with the NRF2/Bach1 Program. HIGH POINT, N.C., Sept. 11, 2019 (GLOBE NEWSWIRE) -- (NASDAQ:), a clinical-stage biopharmaceutical company with leading programs focused on the development of orally administered treatments for diabetes, Alzheimer's disease and inflammatory disorders, today announced it will be presenting posters with new clinical and pre-clinical data from the company's Liver Selective GKA Program and its ...
PubMed News (NIH) 09/11/2019
Contributors : Shunzo Ikarashi ; Atsunori Tuchiya ; Shuji Terai Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens. Background: Mesenchymal stem cells (MSCs) can be acquired from medical waste. MSCs are easily expanded and have multiple functions, including anti-inflammatory effects. We evaluated the effects of human adipose tissue-derived MSCs (AD-MSCs) and umbilical cord tissue-derived MSCs (UC-MSC) in a dextran sulfate sodium (DSS)-induced mouse model. Methods: Human AD-MSCs and UC-MSCs (1 × 106 cells) were injected intravenously into a 7-day DSS-induced colitis model. The therapeutic effects of cell origin, injection timing, and supernatants obtained from MSC cultures were evaluated. We also analyzed.

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