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The human knee is a triumph of design. The joint, which evolved fairly rapidly from our common ancestor with the chimpanzee to accommodate our bipedalism, likely contributed to our success as a species. However, as modern medicine extends the human lifespan, our species have learned pain in the form of osteoarthritis that can accompany the locomotion of this biomechanical masterpiece.
Autism spectrum disorder (ASD) is a set of conditions that affect a baby, toddler or preschooler's mental development. The signs can come on as early as 6 months, but usually, in India, diagnosis happens around 3-5 years. ASD is diagnosed as a problem in social communication- language, non-verbal signs of social interaction, and compulsive interests or activities that the child insists on doing to the exclusion of everything else. Mental retardation, epilepsy, and attention deficit issues may also accompany ASD.
Big data makes big promises when it comes to providing insights into human behavior and health. The problem is how to harness the information it provides in an efficient manner. An international team of researchers has proposed a microbiome search-based method, via Microbiome Search Engine, to analyze the wealth of available health data to detect and diagnose human diseases.
People around the world are isolating themselves to help slow the spread of COVID-19. But there is another way those confined to their homes—but connected online—can join the fight against the novel coronavirus. Among the research programs racing to develop therapies and vaccines for this new pandemic virus is one of the largest crowdsourced supercomputing projects in the world.
Healthy aging has become one of the priorities of research in Europe. University of Tartu researchers looked for differences in the immune systems of young and old people with a focus on monocytes; they found that the monocytes of the elderly do not seem to produce as much energy, and there is an increase in inflammation markers compared to younger people. Looking into the future, this research could contribute to slowing down age-related changes.
Mutations in the nuclear structural protein lamin A produce rare, tissue-specific diseases called laminopathies. To study these diseases, researchers from the Gasser group introduced a mutation inducing a human laminopathy in C. elegans and monitored its effect on chromatin. Not only did they understand the molecular basis of the disease, they found a way to counteract the dominant defects of the mutation, suggesting a novel therapeutic pathway.
Why do some people feel like they need three cups of coffee just to get through the day when others are happy with only one? Why do some people abstain entirely? New research suggests that our intake of coffee—the most popular beverage in America, above bottled water, sodas, tea, and beer—is affected by a positive feedback loop between genetics and the environment.
Netherton syndrome, a rare skin disease caused by a single genetic mutation, is exacerbated by the presence of two common Staphylococcal bacteria living on human skin, one of which was previously thought to only offer protective properties, report University of California San Diego School of Medicine researchers.

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