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Immuno-Oncology News 05/12/2020 10:30
A potential CAR T-cell therapy by Innovative Cellular Therapeutics (ICT) showed early signs of safety and efficacy, significantly reducing tumor size in four patients with thyroid or colorectal cancer, new data show. These findings will be shared in two presentations this Friday, May 15, at the ongoing 23rd American Society of Gene & Cell Therapy Annual […]. .
Immuno-Oncology News 05/05/2020 14:00
A subset of women with recurrent or advanced endometrial cancer, whose disease progressed on or after platinum-based chemotherapy, achieved clinically meaningful responses after treatment with dostarlimab, results of a Phase 1 clinical trial show. The findings, “Safety and efficacy of the anti–PD-1 monoclonal antibody dostarlimab in patients with recurrent or advanced dMMR endometrial cancer,” were […]. .
Immuno-Oncology News 04/14/2020 14:00
The U.S. Food and Drug Administration (FDA) has now given fast track status to Agenus’ balstilimab — both alone and in combination — as an immunotherapy candidate for advanced metastatic cervical cancer. This designation, given separately to these different treatment approaches, is meant to help speed its development by facilitating discussions with the FDA and enabling the therapy to qualify […]. .
Immuno-Oncology News 03/31/2020 10:30
The U.S. Food and Drug Administration (FDA) has approved Imfinzi (durvalumab), in combination with standard chemotherapy, as an initial treatment of people with extensive-stage small cell lung cancer (SCLC). This decision was based on findings from the CASPIAN Phase 3 trial (NCT03043872), in which the combination was found to be better than standard chemo alone at extending […]. .
Immuno-Oncology News 03/24/2020 08:00
First-line treatment with Imfinzi (durvalumab) combined with standard chemotherapy significantly prolongs the life of people with extensive-stage small cell lung cancer (SCLC), final results of the CASPIAN Phase 3 trial show. Approval of the combination for this type of aggressive lung cancer is under review by regulatory authorities in the U.S., E.U., and Japan. In […]. .
Immuno-Oncology News 03/20/2020 08:00
The U.S. Food and Drug Administration (FDA) has approved Harbour BioMed’s investigational new drug applications to initiate U.S. clinical trials testing two of its immunotherapy candidates — HBM9167 and HBM4003 — in several cancers. HBM9167 and HBM4003 are immune checkpoint inhibitors designed to boost the body’s anti-tumor responses by blocking the proteins that cancer cells use to […]. .
Immuno-Oncology News 03/09/2020 08:00
Transgene’s TG6002 has been successfully given to a first person in a Phase 1/2a clinical trial testing it in colorectal cancer patients with inoperable liver metastasis, the company announced. The treatment, delivered directly into the liver by infusion into the hepatic artery (intrahepatic artery infusion), is a next-generation immunotherapy that makes use of a Vaccinia […]. .

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