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Healio News 09/22/2020 13:17
Although typically a benign finding, right bundle branch block may be associated with increased risk for low exercise tolerance, CVD and death, even in patients with no prior CVD, researchers reported. A review of the Mayo Clinic integrated stress center database for exercise stress tests of 22,806 patients from Minnesota found that individuals with right bundle branch block experienced heightened risk for all-cause mortality, CV death, hypertension, low aerobic capacity, slow heart rate recovery and dyspnea, irrespective of CVD status. “One possible pathophysiological mechanism by which.
Healio News 09/22/2020 13:16
The FDA granted priority review to idecabtagene vicleucel for the treatment of certain adults with relapsed or refractory multiple myeloma, according to the agent’s developers. The designation applies to use of idecabtagene vicleucel (Bristol Myers Squibb, bluebird bio) — often called ide-cel — by patients who have received at least three previous therapies, including an immunomodulatory agent, proteasome inhibitor and anti-CD38 antibody. Ide-cel is an autologous chimeric antigen receptor T-cell therapy that targets the B-cell maturation antigen (BCMA) when it is expressed on.
Healio News 09/22/2020 13:05
Adults with rheumatoid arthritis are 23% more likely to develop type 2 diabetes than individuals without the disease, suggesting that an inflammatory response may drive both conditions, according to findings from a meta-analysis. “Accumulating evidence shows that inflammation emerges as a key factor in the onset and progression of diabetes,” Zixing Tian, a doctoral student in the division of diabetes, endocrinology and gastroenterology at Manchester Academic Health Science Centre, the University of Manchester, United Kingdom, told Healio. “Systemic inflammation associated.
Healio News 09/22/2020 12:50
Earlier this month, phase 3 trials for AstraZeneca’s COVID-19 vaccine candidate were halted due to a suspected serious adverse reaction in a participant from the United Kingdom. The trials have since resumed in the U.K. Healio spoke with Paul A. Offit, MD, director of the Vaccine Education Center at Children’s Hospital of Philadelphia, about the logistics behind stopping and restarting a vaccine trial and what it could mean for attitudes about a COVID-19 vaccine when one is available. – by Caitlyn Stulpin A: Usually the data safety monitoring board and then they report that to.
Healio News 09/22/2020 12:35
Sotorasib demonstrated encouraging anticancer activity among patients with heavily pretreated advanced non-small cell lung cancer who harbor KRAS G12C mutations, according to phase 1 study results presented at ESMO Virtual Congress 2020. “Despite the discovery of the KRAS oncogene almost 4 decades ago, there is no approved therapy targeting this,” David S. Hong, MD, deputy chair of the department of investigational cancer therapeutics at The University of Texas MD Anderson Cancer Center, said during a presentation of the findings, published simultaneously in The New England Journal.
Healio News 09/22/2020 12:30
An analysis from clinical trials and natural history studies showed a statistically significant difference in visual outcomes between Lumevoq-treated patients and untreated patients, according to a press release from GenSight Biologics. In patients with Leber hereditary optic neuropathy, eyes treated with Lumevoq (GS010; lenadogene nolparvovec) showed progressive and sustained improvement from month 12 to month 52, while untreated eyes showed an “absence of recovery” over the same period. The difference became statistically significant at month 18 (P = .01). At month 48, the.
Healio News 09/22/2020 12:12
Patients meet clinical quality targets equally at dialysis facilities that participate vs. centers that do not participate in randomized clinical trials, according to presented research. “The global burden of chronic kidney disease is higher than most chronic diseases,” Kurt Mussina, MBA, said at the American Nephrology Nurses Association National Symposium, adding that the approximately 5% of chronic kidney disease cases that progress to end-stage renal disease “is attributable to almost 1 million deaths each year, and it is the only chronic condition universally covered by.
Healio News 09/22/2020 11:45
Higher fibroscan liver stiffness after hepatitis C antiviral treatment was associated with the development of decompensated cirrhosis, according to study results. “There are many routinely available clinical and laboratory predictors of the development of liver-related complications after anti-viral treatment, including age, a clinical diagnosis of cirrhosis, fibrosis-4 score, model for end-stage liver disease score and viral clearance by sustained virological response,” George N. Iaonnou, MD, MS, of Veterans Affairs Puget Sound Healthcare System, and colleagues wrote. “It is.
Healio News 09/22/2020 11:00
Management of ocular surface disorders may be needed for patients who are on dupilumab to treat atopic dermatitis, according to a presentation at the American Academy of Dermatology virtual meeting. The retrospective chart review included patients who received at least 52 weeks of dupilumab treatment or discontinued before 52 weeks due to ocular surface disorders. Conjunctivitis and conjunctivitis-related symptoms, including red eyes, dry eyes, discharge and blepharitis, were assessed. “Conjunctivitis is an ongoing safety concern associated with dupilumab treatment for AD,” the study.
Healio News 09/22/2020 10:43
The addition of ipatasertib to abiraterone enhanced antitumor activity and improved radiographic PFS as first-line therapy for metastatic castration-resistant prostate cancer, according to data presented at ESMO Virtual Congress 2020. Researchers observed these benefits in the randomized phase 3 IPATential150 study among men whose tumors had PTEN loss. “Metastatic castration-resistant prostate cancer [mCRPC] is a heterogeneous disease, with approximately half of these tumors having lost the AKT phosphatase PTEN, hyperactivating oncogenic PI3K/AKT signaling,” Johann S. de Bono, MD,
Healio News 09/22/2020 10:36
Although patient satisfaction is high, an analysis of the literature measuring satisfaction after total shoulder arthroplasty revealed inconsistencies in assessment methods, according to published results. In January 2018, Richard N. Puzzitiello, MD, and colleagues conducted a systematic review of 47 studies that assessed patient satisfaction after anatomic total shoulder arthroplasty (TSA) using the MEDLINE database. They evaluated each study for quality, reported satisfaction rate and satisfaction assessment method. According to the study, 85.1% of the available literature (n = 40) clearly.
Healio News 09/22/2020 10:27
Latent tuberculosis infection therapy in maintenance dialysis may be safe if combined with close follow-up and monitoring, according to results from a recently published study. “World Health Organization guidelines recommend latent tuberculosis infection (LTBI) screening and treatment in maintenance dialysis patients ... However, several potential barriers to LTBI therapy are encountered in this population, including the perception that maintenance dialysis patients are at increased risk of adverse events from LTBI therapy,” Leslie Y. Chiang, BSc, of the British Columbia Centre for.
Healio News 09/22/2020 10:26
In ACS, low-dose colchicine plus standard medical therapy for 12 months resulted in a lower, but statistically insignificant, rate of the composite primary outcome vs. placebo and standard therapy, a speaker reported. However, when this randomized controlled COPS trial was extended to a 400-day follow-up, with participants halting colchicine at 365 days, investigators observed a significant reduction in the primary endpoint, driven by reduced incidence of urgent revascularization and unstable angina. According to findings presented at the virtual European Society of Cardiology Congress, the.
Healio News 09/22/2020 10:26
A 78-year-old woman presented to the Lahey Hospital Cornea Service for evaluation and management of new conjunctival pigmentation of the left eye. She described decreased vision of the left eye associated with mild photophobia. She had no eye pain, redness, flashes, floaters or vision changes in the right eye. Nine months before presentation, she had a mechanical fall with a blunt trauma injury to her left eye. Per the patient’s outside hospital records, immediately after the ocular injury, her vision was light perception in the left eye with an IOP of 49 mm Hg. Her exam showed bullous.
Healio News 09/22/2020 10:26
Welcome to another edition of CEDARS/ASPENS Debates. CEDARS/ASPENS is a joint society of cornea, cataract and refractive surgery specialists, here to discuss some of the latest hot topics in ophthalmology. Before the advent of corneal cross-linking and scleral lenses, many patients with keratoconus who developed significant steepening and poor vision required a corneal transplant, which has its own risks, and leads to a lifetime of maintenance and potentially multiple future procedures. Fortunately, many of these patients can now achieve excellent vision and long-term stability without this.
Healio News 09/22/2020 10:26
Click here to read the Cover Story, "Strategies for sustained anti-VEGF delivery aimed at consistent dosing, durability." There are long-term concerns about gene therapy for a number of reasons. First, across the disease stages, there are various levels of anti-VEGF needed. Although age-related macular degeneration appears to be a chronic condition, a small percentage but significant number of patients do not need chronic therapy and can be managed with a low number of injections. In the CATT trial, 14% of patients on average received one or two injections over a 2-year period, and other.
Healio News 09/22/2020 10:25
A novel method that stimulates the metabolic processes and natural regeneration of cells treats dry eye disease safely and comfortably, according to one specialist. “It is safe and easy; the patient sits comfortably for 20 minutes and just feels a gentle warmth on the eyes. Four sessions, once a week, are the complete course of the treatment, but the benefits are already experienced after the first session,” Brendan Cronin, MBBS (Hons), GradDipOphthSc, FRANZCO, an ophthalmologist practicing at the Queensland Eye Institute in Brisbane, Australia, told Ocular Surgery News. Rexon-Eye.
Healio News 09/22/2020 10:25
The most common drugs injected into the vitreous to treat posterior segment disease are steroids and anti-VEGF medication. To keep it simple, I will use trade names when available. For steroid delivery to the posterior segment, we have Triesence (triamcinolone acetonide injectable suspension, Novartis), Ozurdex (dexamethasone intravitreal implant, Allergan), Yutiq (fluocinolone acetonide intravitreal implant 0.18 mg, EyePoint Pharmaceuticals), Iluvien (fluocinolone acetonide intravitreal implant 0.19 mg, Alimera Sciences) and Vitrasert (ganciclovir). These FDA-approved treatments allow.
Healio News 09/22/2020 10:25
“There ain’t no cure for the summertime blues.” Man, what a weird summer, eh? You were at work, sure, but work was not even a little bit normal. If you are in private practice like I am, you quickly got buried in the work you would have done during the pandemic lockdown. Of course, you also had to plow through all of the extra work the lockdown caused because so many of your patients, especially those with dry eye disease, got so much worse because they had to miss appointments. Those of you in academic practices reportedly had the additional challenges posed by countless.
Healio News 09/22/2020 10:25
Cataract surgery in eyes with small pupils is a challenge, and having a history of uveitis makes it even more so due to the iris synechiae that tend to form. Having a glaucoma seton device in the eye makes it even more difficult because the fluidic balance of phaco surgery is altered due to the additional outflow pathway (Figure 1). These challenging uveitic cataract cases can be successfully completed using a stepwise approach. Patients with uveitis often have recurrent bouts of inflammation that come and go over the course of many years. Because cataract surgery is largely elective, we can.

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