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PubMed News (NIH) 10/22/2020
Contributors : Yin Li ; Laura Wharey ; Kevin Gerrish ; Jian-Liang Li Series Type : Methylation profiling by genome tiling array Organism : Homo sapiens. Estrogen insensitivity syndrome (EIS) arises from rare mutations in estrogen receptor α (ERα, encoded by ESR1 gene) resulting in the inability of estrogen to exert its biological effects.
PubMed News (NIH) 10/22/2020
Contributors : Alyxzandria M Gaydosik ; Dawn S Queen ; Oleg E Akilov ; Larisa J Geskin ; Patrizia Fuschiotti Series Type : Expression profiling by genome tiling array Organism : Homo sapiens. The signal transducer and activator of transcription 6 (STAT-6) is a critical up-stream mediator of IL-13 and IL-4 signaling and is constitutively activated in malignant lymphocytes from Sezary syndrome (SS) and mycosis fungoides (MF), the most common subtypes of cutaneous T-cell lymphomas.
PubMed News (NIH) 10/22/2020
Contributors : Federica Rey ; Cecilia Pandini ; Bianca Barzaghini ; Toniella Giallongo ; Letizia Messa ; Orietta Pansarasa ; Stella Gagliardi ; Matteo Brilli ; Gian V Zuccotti ; Cristina Cereda ; Manuela T Raimondi ; Stephana Carelli Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus. 3D cell cultures are becoming more and more important in the field of regenerative medicine due to their ability to mimic the cellular physiological microenvironment.
Approximately 85% of late-stage clinical trials of candidate drugs fail because of drug safety problems or ineffectiveness, despite promising preclinical test results. To help improve the design and implementation of clinical trials, the National Institutes of Health has awarded 10 grants to support researchers’ efforts in using tiny, bioengineered models of human tissues and organ.
PubMed News (NIH) 10/21/2020
Contributors : Micah A Luftig ; Joanne Dai ; Gregory E Crawford ; Lingyun Song Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. We performed ATAC-Seq on three freshly dissociated human tonsils sorted to purity into the following B-cell subsets: CD19+ naïve (IgD+/CD38-), memory (IgD-/CD38-), germinal center light zone (IgD-/CD38mid/CD83+/CXCR4lo), germinal center dark zone (IgD-/CD38mid/CD83lo/CXCR4hi), and plasma cells (IgD-/CD38hi).

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