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Nipple-sparing mastectomy is gaining ground as a treatment or preventive measure for breast cancer, given the understandable desire among patients to preserve natural appearance as much as possible. But the precise risk of preserving the nipple is not known as the cancer can spread along mammary ducts and to the nipple. A three-dimensional picture of the nipple structure can elucidate much more clearly than conventional reconstructions whether, where, and how much the cancer has spread to the nipple.
PubMed News (NIH) 04/08/2020
Contributors : Spencer Arnesen ; Jason Gertz Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Homo sapiens. While breast cancer patients with tumors that express estrogen receptor α (ER) generally respond well to hormone therapies that block ER’s actions, a significant number relapse.
PubMed News (NIH) 04/08/2020
Mus musculus Experiment type Genome variation profiling by high throughput sequencing Summary BET inhibitors are promising therapeutic agents for the treatment of triple-negative breast cancer (TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and their effects on tumor evolution.
PubMed News (NIH) 04/08/2020
Contributors : Jennifer Y Ge ; Franziska Michor ; Kornelia Polyak Series Type : Genome variation profiling by high throughput sequencing Organism : Homo sapiens. BET inhibitors are promising therapeutic agents for the treatment of triple-negative breast cancer (TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and their effects on tumor evolution.

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